Month: September 2020

184637-48-7, tert-Butyl 3-aminopiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

184637-48-7, A mixture of tert-butyl piperi din-3 -ylcarbamate (70 A) (1.5 g, 7.29 mmol), 4- (trifluoromethoxy)phenylboronic acid (1.5 g, 7.29 mmol), Cu(OAc)2 (1.57 g, 8.75 mmol), and K3PO4 (3.09 g, 14.58 mmol) in DMSO (30 mL) was stirred at 80 C overnight. The mixture was cooled down to room temperature, diluted with water (100 mL), and extracted with EtOAc (50mL x 3). The combined extracts were concentrated under reduced pressure. The residue was purified with column chromatography on silica gel (ethyl acetate in petroleum ether, 10% v/v) to furnish Compound 70B. LC-MS (ESI) m/z: 361 [M+H]+.

The synthetic route of 184637-48-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BIOMARIN PHARMACEUTICAL INC.; WANG, Bing; CHAO, Qi; (737 pag.)WO2019/133770; (2019); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

91419-49-7, 1-Boc-3-Carbamoylpiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

91419-49-7, tert-Butyl 3-carbamothioyIpiperidine-l-carboxylate (92):Amide 91 (2.0 g, 8.76 mmol) and Lawesson’s reagent (1.79 g, 4.42 mmol) were stirred in toluene (45 niL) and the mixture heated to 62 C for 4 hours. The mixture was treated with 5 g of silica gel and 15 mL of methanol, and evaporated to dryness. The solid residue was chromatographed over 30 g of silica gel, eluting with CH2Cl2IMeOH (96:4). The product was chromatographed again, eluting with CH2CbMeOH (97:3) and dried to 1.33 g of 92 as a white foam. MS (ESI) m/z 283 [M+K]+. 1H NMR (CDCl3) delta 1.30-1.50 (m, 10 H), 1.55-1.65 (bs, IH), 1.9-2.0 (m, IH), 2.0-2.2 (m, IH), 2.60-2.75 (bs, IH), 3.0-3.2 (bs, IH), 3.3-3.45 (bs, IH), 3.6-3.95 (m, 2H), 7.43 (bs, 2H).

As the paragraph descriping shows that 91419-49-7 is playing an increasingly important role.

Reference£º
Patent; MITHRIDION, INC.; TWOSE, Trevor, M.; ABRAHAM, Brent, D.; COPP, Richard, R.; FARNHAM, James, G.; HANSON, Seth, A.; HENDRICKSON, Michael, L.; OCKULY, Jeffrey, C.; VERDONE, Melinda, L.; WO2010/102218; (2010); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.189442-78-2,1-Boc-N-methoxy-N-methylpiperidine-3-carboxamide,as a common compound, the synthetic route is as follows.

A solution of tert-butyl 3 -(methoxy(methyl)carbamoyl)piperidine- I -carboxylate (1.0 g, 3.7mmol) in 5 ml of DCM was charged with 5 ml of TFA and stirred at room temperature for one hour. The mixture was then concentrated in vacuo and azeotroped twice with toluene. Theresidue was then diluted with 5 ml of THF and 5 ml of methanol and charged withpropionaldehyde (450 mg, 7.7 mmol) and Sodium Triacetoxyborohydride (1.6 g, 7.7 mniol).The mixture was then stirred at room temperature for one hour and concentrated in vacuo. Themixture was then diluted with ethyl acetate and water. The aqueous was discarded and the organic layer was washed once with water, dried over Na2SO4, filtered, and concentrated in vacuo. The residue was then purified by silica-gel chromatography (1 -10% MeOH in DCM) to afford the the title compound (600 mg, 73% yield).

189442-78-2, The synthetic route of 189442-78-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.; ALBRECHT, Brian, K.; COTE, Alexandre; GEHLING, Victor; HSIAO-WEI TSUI, Vickie; KIEFER, James, Richard, Jr.; LIANG, Jun; MAGNUSON, Steven; NASVESCHUK, Christopher, G.; PASTOR, Richard; ROMERO, F. Anthony; TAYLOR, Alexander, M.; ZHANG, Birong; (287 pag.)WO2016/112284; (2016); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

883984-95-0, Benzyl 7′-chloro-2′-oxo-1′,2′-dihydrospiro[piperidine-4,4′-pyrido[2,3-d][1,3]oxazine]-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

883984-95-0, Step 3: spiro[piperidine-4,4′-pyrido[2,3-d][1,3]oxazin]-2′(1’H)-one hydrochloride 16.40 g (0.04 mol) benzyl 7′-chloro-2′-oxo-1′,2′-dihydrospiro[piperidine-4,4′-pyrido[2,3d]-[1,3]oxazine]-1-carboxylate and 2.00 g palladium(Pd/C 10%) in 500 mL EtOH were hydrogenated for 6 h at RT in a hydrogen atmosphere. Then 1 g of palladium (Pd/C 10%) were additionally added and the mixture was hydrogenated for a further 3 h at RT in a hydrogen atmosphere. After filtration of the reaction mixture the solvent was eliminated in vacuo. The residue was triturated with EtOH, the precipitate formed was suction filtered, washed with EtOH and dried in the drying cupboard for 3 h at 50 C.Yield: 5.40 g (50% of theoretical)ESI-MS: m/z=220 (M+H)+ Rt(HPLC): 0.90 min (method C)

The synthetic route of 883984-95-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; US2012/149698; (2012); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

28936-94-9, 8-Benzyl-1,3,8-triazaspiro[4.5]decane-2,4-dione is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a 20 L reactor 2.4 kg sodium hydroxide were dissolved in 10 L water. The solution was mixed with 614 g 1.38 (8-benzyl-1 ,3,8-triaza-spiro[4.5]decane-2,4-dione) and the resulting reaction suspension was heated to 80C. When 80C was reached, the reaction mixture was heated in steps of 10C. When the temperature reached 105C the mixture started to foam strongly. Stirring was continued at 108C overnight. The reaction mixture was cooled to 10C and 5 L concentrated hydrochloric acid were added dropwise to obtain a pH 7-8. During the addition the temperature was kept at 23C. The precipitate was filtered and dried in vacuo at 40C over 3 days, then at 80C overnight.Yield: 469.7 g I.39 (85% of theory), 28936-94-9

The synthetic route of 28936-94-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; DAHMANN, Georg; FIEGEN, Dennis; FLECK, Martin; HOFFMANN, Matthias; KLICIC, Jasna; EAST, Stephen, Peter; NAPIER, Spencer, Charles, R.; SCOTT, John; WO2012/101013; (2012); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1215071-17-2,tert-Butyl 3,3-difluoro-4-oxopiperidine-1-carboxylate,as a common compound, the synthetic route is as follows.,1215071-17-2

[00411] Step 1: Synthesis of tert-butyl 4-(benzylamino)-3,3-difluoropiperidine-1- carboxylate. To a solution of tert-butyl 3,3-difluoro-4-oxopiperidine-1-carboxylate (1.0 g, 4.25 mmol) in DCM (15 mL) was treated with BnNH2(689 mg, 6.38 mmol) followed by addition of NaBH(OAc)3(2.71 g, 12.76 mmol) and the suspension was stirred at room temperature for 16 h., quenched with aqueous NaHCO3solution (10 mL) and extracted with DCM (30 mL x 2). The combined organic layers were washed with water (20 mL x 3) and brine (20 mL), dried over Na2SO4, filtered and concentrated. The resulting residue was purified by preparative TLC (petroleum ether/EA = 3/1) to give tert-butyl 4-(benzylamino)- 3,3-difluoropiperidine-1-carboxylate (570 mg, 41% yiled) as a colorless oil. ESI-LCMS (m/z): 327.2 [M+1]+.

1215071-17-2 tert-Butyl 3,3-difluoro-4-oxopiperidine-1-carboxylate 56776981, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; EPIZYME, INC.; CHESWORTH, Richard; MORADEI, Oscar, Miguel; SHAPIRO, Gideon; JIN, Lei; BABINE, Robert, E.; (495 pag.)WO2016/44641; (2016); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.625471-18-3,(S)-tert-Butyl 3-aminopiperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

(S)-tert-butyl 3-(l ‘-oxo-2 ‘ ,3 ‘-dihydro- 1 -spiro [cyclobutane- 1 ,4 ‘-pyrazino [1 ,2- a]indol]-7′-ylcarboxamido)piperidine-l-carboxylate (1): To a mixture of -oxo-2′,3′-dihydro- H-spiro[cyclobutane-l,4′-pyrazino[l,2-a]indole]-7’-carboxylic acid (intermediate 7, Example 78; 150 mg, 0.55 mmol) and (S)-tert-butyl 3-aminopiperidine-l-carboxylate (111 mg, 0.55 mmol) in dry DMF (5.0 mL) were added DMAP (169 mg, 1.38 mmol) followed by EDCI.HC1 (213 mg, 1.11 mmol). The resultant reaction mixture was stirred at room temperature under nitrogen atmosphere for 14 h. The reaction mixture was diluted with ice water (50 mL) and extracted with EtOAc (2 x 50 mL). The combined organic layers were further washed with brine solution (20 mL), dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to obtain 1 (190 mg, 76percent) as white solid. 1H NMR (500 MHz, DMSO-d6): delta 1.37 (s, 9H), 1.45 (m, 2H), 1.60 (m, 1H), 1.73 (m, 1H), 1.90 (m, 1H), 2.07 (m, 3H), 2.30 (m, 2H), 2.98 (m, 2H), 3.70 (m, 3H), 3.81 (m, 2H), 7.13 (s, 1H), 7.63 (d, J = 8.0 Hz, 1H), 7.74 (d, J = 8.5 Hz, 1H), 8.30 (m, 2H), 8.35 (s, 1H). MS m/z (M+H): 453.0

625471-18-3, 625471-18-3 (S)-tert-Butyl 3-aminopiperidine-1-carboxylate 1501975, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; CELGENE AVILOMICS RESEARCH, INC.; ALEXANDER, Matthew David; MCDONALD, Joseph John; NI, Yike; NIU, Deqiang; PETTER, Russell C.; QIAO, Lixin; SINGH, Juswinder; WANG, Tao; ZHU, Zhendong; WO2014/149164; (2014); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.141699-59-4,tert-Butyl 4-((methylsulfonyl)oxy)piperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

2.08 kg of cesium carbonate,0.78 kg of 4-bromopyrazole was dissolved in 4 liters of N-methylpyrrolidone,Heated to 80 degrees,A 5 liter solution of N-methylpyrrolidone was added to 1.8 kg of compound (CZT-7)Reaction for 12 hours.Cooled to room temperature,Add 50 litersMethyl tert-butyl etherwith50 liters of water,Stir for 1 hour.After dispensing,The organic phase was washed with 20 liters of * 4 water and dried 50percentLiter of hexane and stirred at room temperature for 2 hours. Filtered and dried to give 1.35 kg of compound (CZT-8) in a yield of 77percent

141699-59-4, As the paragraph descriping shows that 141699-59-4 is playing an increasingly important role.

Reference£º
Patent; Shanghai Aikangrui Pharmaceutical Technology Co., Ltd.; Fan Linfeng; Zhu Yangwei; Xu Zhonghui; Zhang Changxuan; Shi Peng; Qiu Aiyun; (11 pag.)CN106317024; (2017); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.120014-07-5,2-((1-Benzylpiperidin-4-yl)methylene)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one,as a common compound, the synthetic route is as follows.

To 200 mL of toluene were added 20 g of 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-ylidene]methyl-piperidine and 2 g of 10% palladium-carbon. Hydrogenation was carried out with stirring for 5 hours at 0 to 1 C. and 0.8 to 1.0 MPa. HPLC Purity of the Reaction Solution: the desired compound/72.9%, the starting material/25.3%, the debenzylated product/1.8%.

120014-07-5, As the paragraph descriping shows that 120014-07-5 is playing an increasingly important role.

Reference£º
Patent; Eisai R&D Management Co., Ltd.; US2007/88055; (2007); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.625471-18-3,(S)-tert-Butyl 3-aminopiperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

625471-18-3, 1, 1-Dimethylethyl-(3S)-3-aminopiperidine-1-carboxylate (2g, 11mmol), 4H- tetrahydropyran-4-one (1. lg, llmmol) and dichloroethane (40mL) were stirred under nitrogen at room temperature for 15 min. Sodium triacetoxyborohydride (2.9g, 14mmol) was added in 3 lots over 30 minutes and stirred overnight. The reaction was diluted with water (50mL) and made basic by addition of 2N NaOH solution. After stirring for lh, the mixture was extracted into dichloromethane, and the combined organic extracts washed with brine, dried (MgSO4), filtered and evaporated in vacuo to give the title compound as an oil

The synthetic route of 625471-18-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ELI LILLY AND COMPANY; WO2005/60949; (2005); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem