Day: September 25, 2020

91419-49-7, 1-Boc-3-Carbamoylpiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

91419-49-7, 3(B) 3-Cyano-piperidine-1-carboxylic acid tert-butyl ester Phosphorus oxychloride (0.64 mL, 6.89 mmol) was added dropwise at 0 C. to a solution of 3-carbamoyl-piperidine-1-carboxylic acid tert-butyl ester (1.58 g, 6.89 mmol) in pyridine (15 mL), under nitrogen atmosphere. After stirring overnight at room temperature, ethyl acetate was added and the solution was washed with 10% HCl (2 times). The phases were separated and the organics were dried over sodium sulphate and evaporated to dryness under reduced pressure. The title compound was used for the next step without further purification. Yield: quantitative; LCMS (RT): 4.48 min (Method A); MS (ES+) gave m/z: 211.1.

The synthetic route of 91419-49-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NIKEM RESEARCH SRL; ADDEX PHARMA SA; US2009/215822; (2009); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.675-20-7,Piperidin-2-one,as a common compound, the synthetic route is as follows.

10300] To a solution of compound 1 (31.00 g, 312.72 mmol) in CH3CN (500 mE) was added TEA (63.29 g, 625.44 mmol), 13oc20 (88.73 g, 406.54 mmol), DMAP (1.91 g, 15.64 mmol) in portions under N2. The mixture was stirred at 18 C. for 16 hours. TLC showed the reaction was completed. The mixture was concentrated in reduced pressure at 35 C. The residue was purified by silica gel chromatography (PE/EA30/1 to 5/1) to afford compound 2 (41.90 g, 210.29 mmol, 67.25% yield) as yellow oil. LCMS:200 [M+1]., 675-20-7

675-20-7 Piperidin-2-one 12665, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Novira Therapeutics, Inc.; Hartman, George D.; Kuduk, Scott; (85 pag.)US2016/272599; (2016); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.782501-25-1,1-Boc-4-Chlorosulfonylpiperidine,as a common compound, the synthetic route is as follows.,782501-25-1

Example 128 and 129: tert-Butyl 4-(N-(5-(2-methoxyphenyl)-1,3,4-thiadiazol-2- yl)sulfamoyl)piperidine-1-carboxylate, 128 and N-(5-(2-methoxyphenyl)-1,3,4- thiadiazol-2-yl)piperidine-4-sulfonamide hydrochloride, 129 a) tert- butyl 4-(N-(5-(2-methoxyphenyl)-1,3,4-thiadiazol-2-yl)sulfamoyl)piperidine-1- carboxylate 128 Lithium bis(trimethylsilyl)amide solution 1.0 M in THF (0.386 mL, 0.386 mmol) was added to a solution of 5-(2-methoxyphenyl)-1,3,4-thiadiazol-2-amine 1109 (0.040 g, 0.193 mmol) in tetrahydrofuran (1.93 mL) at -10 C and the reaction was stirred for 10 min. A solution of tert-butyl 4-chlorosulfonylpiperidine-1-carboxylate (0.066 g, 0.232 mmol) in THF (0.5 mL) was added dropwise, the resulting mixture was warmed to room temperature and stirred overnight. The reaction was quenched with water (5 mL), acidified with 1 M HCI and extracted with EtOAc (3 x 10 mL). The combined organics were washed with brine, dried (MgS04) and concentrated. Purification by column chromatography (4 g silica cartridge, 50- 90% ethyl acetate in petroleum benzine 40-60 C) gave the title compound (0.013 g, 15% yield) as a pale yellow oil. LCMS-C: rt 6.14 min, m/z 453.2 [M-H]-, NMR (400 MHz, CDCIs) d 8.07 (dd, J = 7.9, 1.7 Hz, 1H), 7.47 (ddd, J = 8.4, 7.4, 1.7 Hz, 1H), 7.07 (td, J =7.6, 1.0 Hz, 1H), 7.02 (d, J = 8.4 Hz, 1H), 4.34-4.18 (m, 2H), 3.98 (s, 3H), 3.16 (tt, J = 1 1.9, 3.6 Hz, 1H), 2.80-2.69 (m, 2H), 2.17 (dd, J = 13.6, 3.6 Hz, 2H), 1.77 (qd, J = 12.5, 4.5 Hz, 2H), 1.46 (s, 9H).

As the paragraph descriping shows that 782501-25-1 is playing an increasingly important role.

Reference£º
Patent; CTXT PTY LIMITED; STUPPLE, Paul, Anthony; LAGIAKOS, Helen, Rachel; FOITZIK, Richard, Charles; CAMERINO, Michelle, Ang; NIKOLAKOPOULOS, George; BOZIKIS, Ylva, Elisabet, Bergman; KERSTEN, Wilhelmus, Johannes, Antonius; WALKER, Scott, Raymond; HUBERT, Jonathan, Grant; (0 pag.)WO2020/2587; (2020); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

159635-49-1, tert-Butyl 4-methylenepiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,159635-49-1

To a degassed, cooled (0¡ãC) sample of 11 (1.7 g) was added 9-BBN (17.5 mL of a 0.5 M in THF). The cooling bath was removed and the solution was stirred for 1.5 h at RT. The resulting solution was added, at RT, to a mixture of the sulfone 10 (0.27 g), Pd(dppf)Cl2 (20 mg), triphenyl arsine (25 mg), DMF (2.0 mL), water (0.18 mL) and Cs2CO3 (0.33 g). The resulting mixture was heated at 60¡ãC for 3 h 45 min. After cooling to RT and pouring into water, the pH was adjusted to 11 with 10 percent NaOH and mixture was extracted with EtOAc (3 * 25 mL). The combined organic extracts were dried with brine and MgSO4, filtered and evaporated to give a crude which was further purified by preparative plate chromatography (2000 muM plate; silica adsorbent; 1:1 EtOAc:hexanes eluant) to give the product 12 as a white foam (0.28 g) in 77 percent yield.

159635-49-1 tert-Butyl 4-methylenepiperidine-1-carboxylate 2756808, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; SCHERING CORPORATION; EP1091956; (2004); B1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

157327-41-8, 1-Boc-3-[(Dimethylamino)methylene]-4-oxopiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2,2-Dimethyl-1 -(2-(methylsulfonyl)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)- yl)propan-1-one[00138]To a solution of crude fe/f-butyl 3-((dimethylamino)methylene)-4-oxopiperidine- 1 -carboxylate (see Preparation 2) (10.70 g, 42.1 mmol) and methyl carbamimidothioate hemisulfate (14.05 g, 50.5 mmol, 1 .2 eq.) in DMSO (200 ml_) is added 4M HCI solution in dioxane (1 .1 ml_, 4.2 mmol, 0.1 eq.). The mixture is heated at 130 C overnight. After cooling down to room temperature EtOAc (330 ml_) and DEE (660 ml_) are added, and the organic layer is washed with water (1 L), brine (3 x, each 1 L), dried over Na2S04, and concentrated in vacuo. Purification by flash column chromatography (silica, gradient 100% heptane to 40% EtOAc/heptane) affords 4.6 g (35%, purity 90%) of theintermediate product fe/f-butyl 2-(methylthio)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5/-/)- carboxylate., 157327-41-8

The synthetic route of 157327-41-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERZ PHARMA GMBH & CO. KGAA; ABEL, Ulrich; KRUEGER, Bjoern; KUBAS, Holger; MEYER, Udo; ZEMRIBO, Ronalds; SMITS, Gints; WO2012/85167; (2012); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

2971-79-1, Methyl piperidine-4-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of {3-(5-Chloro-2-difluoromethoxyphenyl)-4-[(pyrazolo[1,5-a]pyrimidine-3-carbonyl)amino]pyrazol-1-yl}acetic acid (500 mg, 1.08 mmol) in DMF (5 mL) was added methyl piperidine-4-carboxylate (232.1 mg, 1.62 mmol), DIEA (279.2 mg, 2.16 mmol), HATU (493.5 mg, 1.30 mmol). The resulting solution was stirred at room temperature overnight. The resulting mixture was concentrated under vacuum. The residue was purified by flash chromatography on silica gel eluting with 3% MeOH in DCM. This resulted in 500 mg (79%) of methyl 1-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5-a]pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)piperidine-4-carboxylate as yellow oil. LCMS (Method 25) [M+H]+=588.1, RT=0.87 min.

2971-79-1, As the paragraph descriping shows that 2971-79-1 is playing an increasingly important role.

Reference£º
Patent; Genentech, Inc.; Zak, Mark Edward; Ray, Nicholas Charles; Goodacre, Simon Charles; Mendonca, Rohan; Kellar, Terry; Cheng, Yun-Xing; Li, Wei; Yuen, Po-Wai; US2015/336962; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

24666-56-6, 3-Aminopiperidine-2,6-dione hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 3-aminopiperidine-2,6-dione (2.00 g, 12.1 mmol, HCl) and methyl 4-bromo-2-(bromomethyl)benzoate (5.10 g, 16.5 mmol) in DMF (50.0 mL) was added TEA (4.92 g, 48.6 mmol). The reaction mixture was stirred at 75 C. for 12 hrs. On completion, the reaction mixture was diluted with water (200 mL) and filtered. The filtered cake was collected. The reaction mixture was concentrated in vacuo. The residue was triturated with EA_H2O=1:1 (50 mL) to give the title compound (1.70 g, 39% yield) as blue solid. 1H NMR (400 MHz, DMSO-d6) delta 10.99 (s, 1H), 7.90 (s, 1H), 7.74-7.66 (m, 2H), 5.14-5.09 (m, 1H), 4.50-4.33 (m, 2H), 2.95-2.86 (m, 1H), 2.70-2.61 (m, 1H), 2.42-2.36 (m, 1H), 2.04-2.01 (m, 1H).

24666-56-6, As the paragraph descriping shows that 24666-56-6 is playing an increasingly important role.

Reference£º
Patent; Kymera Therapeutics, Inc.; Mainolfi, Nello; Ji, Nan; Kluge, Arthur F.; Weiss, Matthew M.; Zhang, Yi; (1443 pag.)US2019/192668; (2019); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

1023595-19-8, 9-Boc-2,9-diazaspiro[5.5]undecane is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of (2R,6R)-4-(7-cyanopyrazolo[1,5-a]pyridin-4-yl)-6-methyl-morpholin-2- yl]methyl trifluoromethanesulfonate (compound 67c, 30 mg, 71 mumol), tert-butyl 2,9- diazaspiro[5.5]undecane-9-carboxylate (27 mg, 0.11 mmol) in ACN (4 mL) was added K2CO3 (20 mg, 0.14 mmol). After being stirred at rt for 3 hrs, the reaction mixture was diluted with ACN, and filtered through celite. The filtrate was concentrated to give a yellow solid. The solid was dissolved in DCM (2 mL), and TFA (1 mL) was added dropwise. The reaction mixture was stirred at rt for 1.5 hrs, then concentrated to give a crude product which was purified by prep- HPLC to afford Example 67 (34 mg) as a light yellow powder. MS: calc?d 427 (MH+), measured 427 (MH+).1H NMR (400 MHz, METHANOL-d4) d 8.02 (d, J = 3.5 Hz, 1H), 7.45 (d, J = 7.8 Hz, 1H), 6.56 (d, J = 7.9 Hz, 1H), 4.39 (br t, J = 9.4 Hz, 1H), 4.14 – 3.98 (m, 1H), 3.81 – 3.52 (m, 4H), 3.43 – 3.35 (m, 1H), 3.32 – 3.23 (m, 5H), 3.14 – 2.86 (m, 2H), 2.81 – 2.63 (m, 2H), 2.20 – 1.62 (m, 7H), 1.57 – 1.39 (m, 1H), 1.31 (d, J = 6.2 Hz, 3H).

1023595-19-8, As the paragraph descriping shows that 1023595-19-8 is playing an increasingly important role.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; LIU, Haixia; SHEN, Hong; ZHU, Wei; HU, Taishan; ZHANG, Zhiwei; DEY, Fabian; (91 pag.)WO2020/52738; (2020); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

883984-95-0, Benzyl 7′-chloro-2′-oxo-1′,2′-dihydrospiro[piperidine-4,4′-pyrido[2,3-d][1,3]oxazine]-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

INTERMEDIATE 13 r-Methylspiro[piperidine-4,4′-pyridor2.3-6?[l,31oxazinl-2Yrff)-oneStep A. Benzyl 7′-chloro-r-methyl-2′-oxo-r.2′-dihydro-lH-spiro[piperidine-4,4′-pyrido[2,3- d [1 ,3″|oxazine]-l -carboxylate; To a 0 C solution of benzyl 7′-chloro-2′-oxo-ll,2′-dihydro-lH-spiro[piperidine- 4,4′-pyrido[2,3-<^[l,3]oxazine]-l-carboxylate (0.56 g, 1.43 mmol) in DMF (14 niL) was added lithium bis(trimethylsilyl)amide (2.86 mL of IM solution, 2.86 mmol) followed by methyl iodide (0.11 mL, 2.28 mmol). After Ih, more methyl iodide was added (0.55 mL, 1.14 mmol). After a further Ih, the reaction was diluted with EtOAc, extracted with water (3x) and brine, dried over MgSO4, filtered, and concentrated under reduced pressure. The crude product was purified by silica gel chromatography, eluting with a gradient of 0 to 4% methanol : dichloromethane to give the title compound (0.47 g). MS 402.0 (M + 1). 883984-95-0, The synthetic route of 883984-95-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERCK & CO., INC.; WO2006/44504; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.252882-61-4,Spiro[indoline-3,4′-piperidin]-2-one,as a common compound, the synthetic route is as follows.

Process 2Production of 1′-{2-(2-trifluoromethoxyphenoxy)acetyl}spiro(indole-3,4′-piperidine)-2(1H)-oneTo a methylene chloride solution (5 mL) of spiro (indole-3,4′-piperidine)-2(1H)-one (50.0 mg, 0.247 mmol), 2-trifluoromethoxyphenoxyacetic acid (58.4 mg, 0.247 mmol), PyBOP (142 mg, 0.272 mmol), and diisopropylethylamine (63.9 mg, 0.494 mmol) were added sequentially at room temperature. The mixture was stirred at the same temperature for 5 hours. The reaction solution was added with water and then extracted with chloroform. The organic layer was dried with anhydrous sodium sulfate, followed by a vacuum concentration. The resultant residue was purified by preparative thin-layer chromatography (hexane:ethyl acetate=1:2) and 1′-{2-(2-trifluoromethoxyphenoxy)acetyl}spiro(indole-3,4′-piperidine)-2(1H)-one (33.0 mg, 31.8%) was obtained as a colorless amorphous solid.1H-NMR (400 MHz, CDCl3) delta; 1.83-1.91 (m, 4H), 3.80-3.86 (m, 1H), 3.90-3.97 (m, 1H), 4.03 (quint, J=6.8 Hz, 1H), 4.24-4.30 (m, 1H), 4.79 (d, J=12.9 Hz, 1H), 4.87 (d, J=12.9 Hz, 1H), 6.91 (t, J=7.8 Hz, 1H), 7.00-7.30 (m, 7H), 8.58 (s, 1H).IR(ATR); 3217,1711,1632,1471,1223,755 cm-1.EI-MS m/z; 420(M+)., 252882-61-4

As the paragraph descriping shows that 252882-61-4 is playing an increasingly important role.

Reference£º
Patent; KOWA CO., LTD.; US2008/306102; (2008); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem