Day: September 24, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.614731-04-3,1-Boc-4-fluoro-4-piperidinecarboxylic Acid,as a common compound, the synthetic route is as follows.

tert-Butyl 4-carbamoyl-4-fluoropiperidine-1-carboxylate (0414) In a 250-mL round-bottom flask were combined 1-[(tert-butoxy)carbonyl]-4-fluoropiperidine-4-carboxylic acid (3 g, 12.13 mmol, 1.00 equiv), DMF (50 mL), NH4Cl (1.75 g, 32.72 mmol, 1.50 equiv), HATU (9.23 g, 24.27 mmol, 2.00 equiv), and iPr2NEt (3.13 g, 24.22 mmol, 2.00 equiv). The resulting solution was stirred overnight at 25 C. The resulting solution was extracted with 200 mL of EtOAc and the organic layers were combined, washed with 5¡Á50 mL of H2O, then applied onto a silica gel column with ethyl acetate/petroleum ether, affording 2.7 g (90%) of the product as a white solid., 614731-04-3

614731-04-3 1-Boc-4-fluoro-4-piperidinecarboxylic Acid 21050397, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Imago Biosciences, Inc.; Rienhoff, JR., Hugh Y.; McCall, John M.; Clare, Michael; Celatka, Cassandra; Tapper, Amy E.; (226 pag.)US2016/237043; (2016); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

173186-91-9, 1-Benzyl-3,3-dimethylpiperidin-4-one is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Preparation 11 4-Methylamino-3,3-dimethylpiperidine Potassium hydroxide (12.85 g, 230 mmol) was added to the stirred solution of methylamine hydrochloride (15.5 g, 230.0 mmol) in methanol (100 ml) and stirring was continued for 30 min at 30 C. 1-Benzyl-3,3-dimethyl-4-piperidone (5 g, 23.0 mmol), was added to the resulting mixture and stirred for 6 hr. Sodium cyanoborohydride (1.45 g, 23.0 mmol) was added to it and reaction mixture was stirred for 15 hr. The reaction mixture was concentrated to dryness, triturated with water, extracted with chloroform, dried (Na2SO4) and concentrated to give 1-benzyl-4-methylamino-3,3-dimethylpiperidine. Yield 5.3 g (99%), C15H24N2, m/z 233 (M+1), PMR (CDCl3): 0.9 (s, 3H), 1.0 (s, 3H), 1.38 (m, 2H), 1.54 (bs, 1H, D2O exchangeable), 1.68-2.1 (m, 4H), 2.4 (s, 3H), 2.86 (m, 1H), 3.4 (dd, 2H), 7.3 (m, 5H)., 173186-91-9

The synthetic route of 173186-91-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Wockhardt Limited; US6878713; (2005); B2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

143900-44-1, (S)-tert-Butyl 3-hydroxypiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,143900-44-1

Step 3. To a stirred mixture of 3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine (5.9 g, 22.6 mmol, 1.00 equiv), (S)-tert-butyl 3-hydroxypiperidine-1-carboxylate (10 g, 50 mmol, 2.2 equiv) and triphenylphosphine (11.8 g, 45 mmol, 2.0 equiv) in tetrahydrofuran (300 mL) at 10 C. was added a solution of diisopropyl azodicarboxylate in tetrahydrofuran (30 mL) dropwise in 30 min. The resulting mixture was stirred at room temperature for 12 h and then concentrated under vacuum. The residue was purified on a silica gel column eluted with dichloromethane/methanol (100/1) to give 3 g (33%) of (R)-tert-butyl 3-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate as yellow solid.

As the paragraph descriping shows that 143900-44-1 is playing an increasingly important role.

Reference£º
Patent; Taunton, JR., John William; Brameld, Kenneth Albert; Goldstein, David Michael; Mcfarland, Jesse; Krishnan, Shyam; Choy, Jonathan; US2014/323464; (2014); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.79099-07-3,1-Boc-4-Piperidone,as a common compound, the synthetic route is as follows.

79099-07-3, 3, 3-DIMETHVL-4-OXO-PIPERIDINE-1-CARBOXYLIC acid ter-butyl ester (88 ; Scheme XXIV was prepared according the procedure described in Vice et al. J. Org. Chem. 2001,66, 2487-2492.

As the paragraph descriping shows that 79099-07-3 is playing an increasingly important role.

Reference£º
Patent; JANSSEN PHARMACEUTICA, N.V.; WO2005/33108; (2005); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

2971-79-1, Methyl piperidine-4-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of Example 340F (9.5 g, 25.1 mmol) and methyl isonipecotate (7.19 g, 50.2 mmol) in DMF (70 ML) was added EDC (9.64 g, 50.2 mmol), HOBt (6.78 g, 50.2 mmol) and triethylamine (7.0 ML, 50.2 mmol).The reaction mixture was stirred at room temperature for 15 hours.ethyl acetate (800 ML) was added, and the mixture was washed with brine, and concentrated.The residue was purified by flash chromatography (60% EtOAc in hexane) to give example 340G as white powder (10.86 g, 94%). MS (ESI+) m/z 503 (M+H)+., 2971-79-1

2971-79-1 Methyl piperidine-4-carboxylate 424914, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Abbott Laboratories; US2004/116518; (2004); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.37675-18-6,(S)-Ethyl piperidine-3-carboxylate,as a common compound, the synthetic route is as follows.

4.3.40 Ethyl (S)-1-(ethoxymethyl)piperidine-3-carboxylate, (S)-10 K2CO3 (2.8?g, 20?mmol) was added to a solution of ethyl nipecotate (3.2?mL, 20?mmol) in EtOH (7.0?mL, 0.12?mol) at 0?C. After 15?min paraformaldehyde (PFA) (0.63?g, 20?mmol) was added, and the mixture was stirred at 25?C for 6?h. The mixture was diluted with Et2O and filtered. The filtrate was concentrated under reduced pressure. The crude product was purified by distillation (Kugelrohr distillation) at 130?C (0.4?Torr) to obtain the product N,O-acetal (rac-10) as a colorless oil (3.1?g, 71%). Analytical data corresponds to those of rac-10 except [alpha]D 20 = +13.3 (c?=?2.0, DCM).

37675-18-6, 37675-18-6 (S)-Ethyl piperidine-3-carboxylate 187784, apiperidines compound, is more and more widely used in various fields.

Reference£º
Article; Toth, Krisztian; Hoefner, Georg; Wanner, Klaus T.; Bioorganic and Medicinal Chemistry; vol. 26; 22; (2018); p. 5944 – 5961;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

79099-07-3,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.79099-07-3,1-Boc-4-Piperidone,as a common compound, the synthetic route is as follows.

To a stirred solution of tert-butyl 4-oxopiperidine-l-carboxylate (step 1, 6.0 g, 30.15 mmol, 1.0 eq) in DCM (60 mL) was added diethylaminosulfmtrifiuoride (DAST) (5.97 mL, 45.22 mmol, 1.5 eq) at 0 C. The reaction mixture was stirred at same temperature for about 6 hours. TLC indicated starting material was consumed and the desired product was observed. The reaction mixture was poured into ice cold water and extracted with DCM. The organic layer was washed with water, brine solution and the organic layer was dried with Na2S04. The filtrate was concentrated to get the crude residue which was purified by column chromatography by using 10% EtOAc and hexane as an eluent to obtain the desired product (6.0 g, yield: 90.0%) as a white solid. 1H NMR (DMSO-d6, 300 MHz): delta 3.45-3.41 (m, 4H), 1.98-1.85 (m, 4H) and 1.40 (s, 9H); Mass: [M+H]+222.53 (20%).

The synthetic route of 79099-07-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; HETERO LABS LIMITED; BANDI, Parthasaradhi Reddy; KURA, Rathnakar Reddy; GAZULA LEVI, David Krupadanam; ADULLA, Panduranga Reddy; MUKKERA, Venkati; NEELA, Sudhakar; (77 pag.)WO2017/149518; (2017); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3970-68-1,4-Methylpiperidin-4-ol,as a common compound, the synthetic route is as follows.

l-(6-Chloropyrazin-2-yl)-3,3-dimethyl-6-(2-methylpyrimidin-5-yl)indolin-2-one (52 mg, 142 mupiiotaomicron, Eq: 1, Example 6a), 4-methylpiperidin-4-ol (24.6 mg, 213 mupiiotaomicron, Eq: 1.5) and potassium carbonate (39.3 mg, 284 mupiiotaomicron, Eq: 2) were combined with acetonitrile (711 mu). The reaction mixture was heated to 100 C and stirred for 3 days until no starting material was left. The residue was purified by chromatography on silica gel to afford the desired product as a light yellow foam (63 mg, 99 %). MS (m/z) = 445.2 [M + H]+.

3970-68-1, As the paragraph descriping shows that 3970-68-1 is playing an increasingly important role.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; GAUFRETEAU, Delphine; KOLCZEWSKI, Sabine; PLANCHER, Jean-Marc; STOLL, Theodor; (99 pag.)WO2017/76842; (2017); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

103816-19-9, [1,4′-Bipiperidine]-1′-carbonyl chloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

SN-38B-11 (1.22 g, 2.08 mmol, yield 89%, enantiopurity 99.8%ee) was obtained from SN-38 (0.91 g, 2 .32 mmol) synthesized in Example 9 by the reported procedure (Sawada, S.; Okajima, S.; Aiyama, R.; Nokata, K.; Furuta, T.; Yokokura, T.; Sugino, E.; Yamaguchi, K.; Miyasaka, T. Chem. Pharm. Bull. 1991, 39, 1446.).Chiral HPLC operation conditions Column: DAICEL CHIRALCEL OD-H, 0.46cmID¡Á25cm (No.ODH0CE-AK031) Guard cartridge: DAICEL CHIRALCEL OD-H, 0.4cmIDxlcm Injection amount:10mug/10muL Temperature: constant temperature about 40C Flow rate: 1mL/min Mobile phase: dimethylamine : hexane : ethanol mixture(1 : 250 : 250) Detect: 254nm

103816-19-9, As the paragraph descriping shows that 103816-19-9 is playing an increasingly important role.

Reference£º
Patent; Kabushiki Kaisha Yakult Honsha; EP1378505; (2004); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.832715-51-2,Isopropyl 4-hydroxypiperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

832715-51-2, Step 3: 1 -Methylethyl 4-({7-[6-(methylthio)-3-pyridinyl]-6,7-dihydro-5H-pyrrolo[2,3- c/]pyrimidin-4-yl}oxy)-1 -piperidinecarboxylate (206) To a stirred solution of 205 (1.31 g, 4.71 mmol) and 1 -methylethyl 4-hydroxy-1- piperidinecarboxylate 9 (1.06 g, 5.65 mmol) in THF (47 ml.) was added NaH (60% dispersion in mineral oil, 565 mg, 14.13 mmol) in one portion at RT. The reaction mixture was heated to reflux for 18 h, cooled to RT, and quenched with water (10 ml_). The mixture was extracted with EtOAc (3 x 75 ml_), dried over MgSO4, filtered, and concentrated under reduced pressure. The crude oil was purified using SiO2 flash chromatography (40% EtOAc in hexanes) to give 500 mg (25%) of the title product 206 as a colorless oil. 1H NMR (400 MHz, CDCI3): delta 8.58 (d, J = 2.7 Hz, 1 H), 8.41 – 8.37 (m, 1 H), 8.27 (s, 1 H), 7.21 (d, J = 8.8 Hz, 1 H), 5.32 (septuplet, J = 3.9 Hz, 1 H), 4.91 (app. quintuplet, J = 6.1 Hz, 1 H), 4.05 (t, J = 8.8 Hz, 2 H), 3.82 – 3.75 (m, 2 H), 3.35 – 3.28 (m, 2 H), 3.08 (t, J = 8.8 Hz, 2 H), 2.59 (s, 3 H), 2.00 – 1.93 (m, 2 H), 1.75 – 1.67 (m, 2 H), 1.24 (d, J = 6.8 Hz, 6 H); LCMS (ESI): m/z 430 (M + H)+.

832715-51-2 Isopropyl 4-hydroxypiperidine-1-carboxylate 16745126, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; SMITHKLINE BEECHAM CORPORATION; WO2008/8895; (2008); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem