Day: September 23, 2020

769944-78-7, 1-N-Boc-4-(4-Bromophenyl)piperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

769944-78-7, A mixture containing 4-(4-bromo-phenyl)-piperidine-1 -carboxylic acid tert-butyl ester (100 mg, 0.29 mmol), 2-tribupsilontylstannanyl-pyrimidi?e (130 mg, 0.36 mmol), cesium fluoride (85 mg, 0.56 mmol) and palladium di-tert-butylphosphine was degassed three times with Ar. Dioxane was added and the formed reaction mixture was stirred at HO 0C overnight under Ar. Then the reaction mixture was filter through celite and the .solvent was removed under vacuum and crude product was used directly in the next step.

The synthetic route of 769944-78-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SCHERING CORPORATION; WO2007/70398; (2007); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.479630-08-5,1-Boc-4-(2-Ethoxycarbonyl-acetyl)piperidine,as a common compound, the synthetic route is as follows.

Tert-butyl 4-(3-ethoxy-3-oxopropanoyl)piperidine-l-carboxylate (1.07 g, 3.58 mmol, 1.5 eq), 4-ethoxy- lH-indazol-3-amine (423 mg, 2.39 mmol, 1 eq) and potassium phosphate (1.01 g, 4.78 mmol, 2 eq) were suspended in l-methoxy-2-propanol (10 mL) in a 20 mL microwave vial. The vial was capped and the mixture was heated in a microwave to 180C for 15 min. After cooling to RT, the suspension was diluted with 20 mL dichloromethane/methanol (4: 1), filtered through a short pad of silica gel with 100 mL dichloromethane/methanol (4: 1) and evaporated in vacuo. The residue was triturated with MTBE (15 mL), filterered, washed with MTBE (2 mL) and dried for 16 h at 50C in vacuo to yield the title compound (161 mg, 15% of theory). LC-MS (Method IB): Rt = 1.11 min, MS (ESIPos): m z = 413 [M+H]+

479630-08-5, 479630-08-5 1-Boc-4-(2-Ethoxycarbonyl-acetyl)piperidine 6618868, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; HASSFELD, Jorma; KINZEL, Tom; KOeBBERLING, Johannes; CANCHO-GRANDE, Yolanda; BEYER, Kristin; ROeHRIG, Susanne; KOeLLNBERGER, Maria; SPERZEL, Michael; BURKHARDT, Nils; SCHLEMMER, Karl-Heinz; STEGMANN, Christian; SCHUHMACHER, Joachim; WERNER, Matthias; ELLERMANN, Manuel; WO2015/67549; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

181269-69-2, tert-Butyl 3-methyl-4-oxopiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of compound 3 (11.00 mmol) in ethanol (50 mL) was added KBH4 (0.712 g, 13.20mmol) slowly at 0 C . The reaction mixture was stirred at 0 Cfor 0.5 h and the stirred at RT for 2 h. The reaction mixture was pure into water (50 mL) and extracted with DCM (50 mL3). The organic layer was dried and concentrated to give the product, 181269-69-2

The synthetic route of 181269-69-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NOVIRA THERAPEUTICS, INC.; HARTMAN, George D.; FLORES, Osvaldo A.; WO2013/96744; (2013); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.134441-61-5,(R)-N-Boc-Piperidine-2-methanol,as a common compound, the synthetic route is as follows.

Trifluoroacetic acid (3 ml) was carefully added to a stirring solution of tert-butyl (2R)-2- (hydroxymethyl) PIPERIDINE-L-CARBOXYLATE (1.15 g, obtained as described in TETRAHEDRON, 5 8 (2002), 1343-1354) in DCM (3 ml) and stirred at room temperature for 1 hour. Volatiles were removed IN VACUO and the oil thus obtained dissolved in methanol (60 ml), and neutralized by addition of MP-Carbonate resin (polymer supported carbonate reagent ex. Argonaut Technologies Inc.) (approximately I g) whilst stirring at room temperature for 2 hours. The resin was filtered, washed with methanol (3 x 30 ml) and the filtrate concentrated. The resulting oil was dissolved in DCM (30 ml) and dried (MgSO4) before filtration and solvent removal to afford a grey oil (615 mg, 100%); NMR spectrum (DMSO-D6) 1.44-1. 51 (m, 2H), 1.61 (m, 1H), 1.70-1. 78 (m, 3H), 2.84 (m, 1H), 3.03 (m, 1H), 3.21 (d, 1H), 3.49 (m, 1H), 3.57 (dd, 1H), 5.01 (bs, 1H), 7.65 (bs, 1H) ; Mass spectrum M+ 116., 134441-61-5

The synthetic route of 134441-61-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2005/26152; (2005); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

1038866-44-2, Spiro[piperidine-4,4′-pyrido[2,3-d][1,3]oxazin]-2′(1’H)-one hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 54(S)-1-(6-(4-methyl-2-(tetrahydrofuran-2-yl)-1H-benzo[d]imidazol-6-yloxy)pyrimidin-4-yl)-spiro[piperidin-4,4′-pyrido[2,3-d][1,3]oxazin]-2′(1’H)-one; 59 mg (0.23 mmol) spiro[piperidin-4,4′-pyrido[2,3-d][1,3]oxazin]-2′(1’H)-one hydrochloride, 70 mg (0.21 mmol) (S)-6-(6-chloropyrimidin-4-yloxy)-4-methyl-2-(tetrahydrofuran-2-yl)-1H-benzo[d]imidazole and 0.12 mL (0.70 mmol) DIPEA in 2.0 mL DMF were stirred overnight at 40 C. The reaction mixture was purified by preparative HPLC-MS. The fractions containing product were partially evaporated down i.vac. and neutralised with 4M sodium hydroxide solution. The precipitate formed was suction filtered, washed and dried.Yield: 21 mg (18% of theory)ESI-MS: m/z=514 (M+H)+ Rt (HPLC): 1.09 min (method B)

1038866-44-2, As the paragraph descriping shows that 1038866-44-2 is playing an increasingly important role.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; US2012/88755; (2012); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

876379-22-5,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.876379-22-5,(S)-1-Cbz-3-Boc-Aminopiperidine,as a common compound, the synthetic route is as follows.

TFA (4 ml) was added to a solution of benzyl (3S)-3-[(2-methylpropan-2-yl)oxycarbonylamino]piperidine-1-carboxylate (487 mg, 1.46 mmol) in DCM (6 ml), and the mixture was stirred at room temperature for one hour. The reaction mixture was concentrated under reduced pressure, and the resultant residue was dissolved in ethyl acetate and a saturated aqueous sodium bicarbonate solution. The separated organic layer was washed with a saturated aqueous sodium chloride solution, and dried over anhydrous sodium sulfate. After the drying agent was removed by filtration, a crude product of benzyl (3S)-3-aminopiperidine-1-carboxylate (501 mg) was obtained as a colorless oily substance by concentration under reduced pressure. LCMS: m/z 235 [M+H]+

The synthetic route of 876379-22-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Chugai Seiyaku Kabushiki Kaisha; MURATA, Takeshi; KAWADA, Hatsuo; NIIZUMA, Satoshi; HARA, Sousuke; HADA, Kihito; SHIMADA, Hideaki; TANAKA, Hiroshi; MIO, Toshiyuki; EP2842946; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

143900-44-1, (S)-tert-Butyl 3-hydroxypiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Diisopropyl diazodicarboxylate (DAID, 1.2 ml) was added to a solution of 1-tert-butyloxycarbonyl-3-(S)-hydroxypiperidine ( 1.0 g,) and triphenylphosphine (2.59g) in tetrahydrofuran (50.0ml). To the resulting yellow solution, 3-(p-phenoxyphenyl)-1,2,5,7-tetraza-1H-inden-4-ylamine (1.0g). was added and warmed till dissolution, and stirred overnight at room temperature. The reaction mixture was filtered and the solvent was distilled under vacuum to get an oily residue, which was further purified by flash chromatography (30-50 % ethyl acetate/ hexane) on silicagel to give 0.3 g (0.3 w/w) of tert-butyloxycarbonyl-(1S)-1-[(3R)-3-piperidyl]-3-(p-phenoxyphenyl)-1,2,5,7-tetraza-1H-inden-4-ylamine as a light brown solid. The resulting solid was dissolved in dichloromethane (5 ml) and trifluoroacetic acid (0.6 ml) was added to it. After completion of reaction, water was added to reaction mass, followed by addition of methyl tert-butyl ether (20.0 ml). The layers were separated and the aqueous layer was basified with potassium carbonate and extracted with dichloromethane (15.0 ml x 2). The organic layer dried over sodium sulfate, filtered and evaporated to yield 0.2 g (0.6 w/w) of title compound as light yellow oil., 143900-44-1

As the paragraph descriping shows that 143900-44-1 is playing an increasingly important role.

Reference£º
Patent; IND-SWIFT LABORATORIES LIMITED; ARUL, Ramakrishnan; SARIN, Gurdeep Singh; WAS, Sandeep; KUMAR, Vishal; (26 pag.)WO2017/163257; (2017); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5382-16-1,4-Piperidinol,as a common compound, the synthetic route is as follows.,5382-16-1

b. 1-(Carbobenzyloxy)piperidin-4-ol A solution of 4-hydroxypiperidine (25.0 g, 0.247 mol) in methylene chloride (2000 mL) was cooled to 0 C. under nitrogen with overhead stirring. Triethylamine (86.1 mL, 0.618 mol, 2.5 eq) was added followed by benzyl chloroformate (35.3 mL, 0.247 mol, 1.0 eq). The reaction was warmed to room temperature over 1 h and maintained at this temperature for 5 h. A significant amount of amine hydrochloride precipitates in the course of the procedure. The organic phase was washed with 3N HCl (3*250 mL), dried over anhydrous sodium sulfate and filtered. The solvent was removed in vacuo to yield 47.0 g (81%) of the title compound as an oil. The product did not require any addition purification prior to the Swern oxidation. TLC analysis (Rf 0.17, 50% ethyl acetate in hexane). MS (CI, CH4) m/z 236 (M+1,42), 218 (4), 192 (10), 181 (9), 174 (15), 91 (100).

5382-16-1 4-Piperidinol 79341, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Zeneca Limited; US5512575; (1996); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

225240-71-1, Ethyl 4-methylpiperidine-4-carboxylate hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

400 mg of [5-({[6- (trifluoromethyl)pyridin-2- yl]carbonyl}amino)-2H- indazol-2-yl]acetic acid were reacted with 296 mg of ethyl 4-methylpiperidine-4- carboxylate hydrochloride (1:1) in the presence of EDC, HOBt and triethylamine. This gave 544 mg of ethyl 4-methyl-1-{[5-({[6-(trifluoromethyl)pyridin-2-yl]carbonyl}amino)- 2H-indazol-2-yl]acetyl} piperidine-4-carboxylate as a crude product. Ethanol and THF and 348 mg of lithium hydroxide monohydrate in water were added, and the mixture was stirred overnight and acidified with citric acid solution. Extraction with ethyl acetate and purification by HPLC gave 89 mg of 4-methyl-1-{[5-({[6-(trifluoro-methyl)pyridin-2-yl]carbonyl}amino)-2H-indazol-2-yl]acetyl}piperidine-4- carboxylic acid. 49 mg of thiswere reacted with 15 mg of 1-methylpiperazine in the presence of EDC, HOBt and triethylamine in THF. Purification by HPLC gave 29 mg of N-[2-(2-{4-methyl-4-[(4-methylpiperazin-1-yl)carbonyl]piperidin-1-yl}-2-oxoethyl)-2H-indazol- 5-yl]-6-(trifluoromethyl) pyridine-2-carboxamide. 1H-NMR (300 MHz,DMSO-d6, selected signals): delta = 1.25 (s, 3H), 1.36-1.57 (m, 2H), 1.98-2.22 (m, 5H), 2.27 (br. s., 4H), 3.13 (t), 3.54 (s), 3.60-3.80 (m, 2H), 5.35-5.50 (m, 2H), 7.51-7.63 (m, 2H), 8.17 (dd, 1H), 8.26-8.42 (m, 4H), 10.37 (s, 1H)., 225240-71-1

225240-71-1 Ethyl 4-methylpiperidine-4-carboxylate hydrochloride 19361804, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Bayer Pharma Aktiengesellschaft; BOTHE, Ulrich; SIEBENEICHER, Holger; SCHMIDT, Nicole; ROTGERI, Andrea; BOeMER, Ulf; RING, Sven; IRLBACHER, Horst; GUeNTHER, Judith; STEUBER, Holger; LANGE, Martin; SCHAeFER, Martina; (191 pag.)US2016/311833; (2016); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.479630-08-5,1-Boc-4-(2-Ethoxycarbonyl-acetyl)piperidine,as a common compound, the synthetic route is as follows.

Tert-butyl 4-(3-ethoxy-3-oxopropanoyl)piperidine-l-carboxylate (1.00 g, 3.34 mmol, 1.5 eq), 6-fluoro- lH-indazol-3-ylamine (337 mg, 2.27 mmol, 1 eq) and potassium phosphate (945 mg, 4.45 mmol, 2 eq) were suspended in l-methoxy-2-propanol (11 mL) in a 20 mL microwave vial. The vial was capped and the mixture was heated in a microwave to 180C for 15 min. After cooling to RT, the suspension was diluted with 20 mL dichloromethane/methanol (4: 1), filtered through a short pad of silica gel with 100 mL dichloromethane/methanol (4: 1) and evaporated in vacuo. The residue was triturated with 4 mL MTBE/ethyl acetate (1 : 1), filterered, washed with ethyl acetate (2 mL) and dried for 16 h at 50C in vacuo to yield the title compound (66 mg, 7% of theory) as colorless solid. LC-MS (Method IB): Rt = 1.01 min, MS (ESIPos): m z = 387 [M+H]+

479630-08-5, The synthetic route of 479630-08-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; HASSFELD, Jorma; KINZEL, Tom; KOeBBERLING, Johannes; CANCHO-GRANDE, Yolanda; BEYER, Kristin; ROeHRIG, Susanne; KOeLLNBERGER, Maria; SPERZEL, Michael; BURKHARDT, Nils; SCHLEMMER, Karl-Heinz; STEGMANN, Christian; SCHUHMACHER, Joachim; WERNER, Matthias; ELLERMANN, Manuel; WO2015/67549; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem