Day: September 22, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.143900-43-0,(R)-tert-Butyl 3-hydroxypiperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

C: (S)-3-(1-amino-isoquinolin-6-yloxy)piperidin-1-carboxylic acid te/t-butyl esterTo a solution of (f?)-3-hydroxypiperidine-1-carboxylic acid te/t-butyl ester (209 mg, 1.04 mmol), triphenylphosphine (327 mg, 1.249 mmol), 1-amino-isoquinolin-6-ol (200 mg, 1.249 mmol) in THF (4 ml) and DMF (394ul_) at 0 C, under argon, was added dropwise diethylazodicarboxylate (197 ml.) over 5 min. The mixture was then warmed to ambient temperature and stirred for 48 h. Water was then added and the mixture basified with dilute NaOH. The mixture was extracted with ethyl acetate (X3), dried (sodium sulphate) filtered and evaporated under reduced pressure to give a residue. Flash chromatography of the residue on silica (eluent: 2-10% methanol in dichloromethane with 1 % aqueous ammonia) gave (S) 3-(1-amino-isoquinolin-6- yloxy)piperidin-1-carboxylic acid te/t-butyl ester (72 mg), EI-MS: m/z = 344.1 [M+H]+., 143900-43-0

143900-43-0 (R)-tert-Butyl 3-hydroxypiperidine-1-carboxylate 1514398, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; N.V. ORGANON; WO2007/65916; (2007); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

1158759-03-5, tert-Butyl ((4-methylpiperidin-4-yl)methyl)carbamate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step a: To a solution of 2-chloro-4-((4-methoxybenzyl)oxy)pyrimidine (118 mg, 0.5 19 mmol), prepared according to the methods in W0201 1022440, in DMF (50 mL) was added tert-butyl ((4-methylpiperidin-4-yl)methyl)carbamate (130 mg, 0.5 19 mmol). The reaction stirred for 48 h and was diluted in EtOAc:water (1:1, 100 mL). The mixture was extracted with EtOAc (3 x) and the combined organic extracts were washed with brine (3 x), dried over Mg504, filtered, and concentrated under reduced pressure to afford crude tert-butyl ((1 -(4-((4- methoxybenzyl)oxy)pyrimidin-2-yl)-4-methylpiperidin-4-yl)methyl)carbamate, as a yellow oil (202 mg) which was used without further purification. MS m/z 443 (M+H).

1158759-03-5, The synthetic route of 1158759-03-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NOVARTIS AG; CHEN, Zhuoliang; FORTANET, Jorge Farcia; LAMARCHE, Matthew J.; SENDZIK, Martin; TAMEZ, JR., Victoriano; YU, Bing; (237 pag.)WO2016/203405; (2016); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.134441-93-3,(S)-1-Boc-2-(Hydroxymethyl)piperidine,as a common compound, the synthetic route is as follows.

General procedure: To a solution of (COCl)2 (1.2mmol) in DCM (10mL) cooled to -78C was added DMSO (1.5mmol). The carbamate protected pipecolinol 10 (a, b, c) (1mmol) was then added drop wise over a period of 5min. The reaction mixture was brought to -50C in 15min and Et3N (3mmol) was added over a period of 5min. It was then stirred for 10min at the same temperature and further stirred at rt for 15min. The reaction mixture was further diluted with DCM (10mL) and the organic layer was washed with very dil HCl (0.1N, 10mL¡Á2) and brine solution (10mL¡Á2). It was then dried over anhyd Na2SO4 and concentrated under reduced pressure to afford aldehyde 11 (a, b, c) as a thick liquid, which without any further purification was immediately consumed for the next reaction.

134441-93-3, As the paragraph descriping shows that 134441-93-3 is playing an increasingly important role.

Reference£º
Article; Bhat, Chinmay; Tilve, Santosh G.; Tetrahedron; vol. 69; 51; (2013); p. 10876 – 10883;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

156185-63-6, tert-Butyl 4-(3-hydroxypropyl)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example D2: 1-Methylcyclopropyl 4-(3-(6-(methylsulfonyl)-5,6,7,8- tetrahydropyrido[4,3-J]pyrimidin-2-yloxy)propyl)piperidine-l-carboxylate. ; Step A: To a stirred solution of tert-butyl 4-(3-hydroxypropyl)piperidine-1-carboxylate (40.6 g, 167 mmol) and pyridine (27 rnL, 184 mmol) in DCM (150 rnL) is slowly added MsCl (14.3 rnL, 184 mmol) over 30 min at 0C. The reaction is then stirred at 0C for 1 h and then at rt overnight. The reaction mixture is partitioned between water (50 mL) and EtOAc (100 mL). The aqueous layer is separated and is further extracted with EtOAc (2×100 mL). The organics are combined and washed with brine (25 mL), dried (MgSO4), and evaporated to give an amber-colored oil. The crude is purified by flash chromatography (SiO2, EtOAc/hexanes gradient) to give tert-butyl 4- (3-(methylsulfonyloxy)propyl)piperidine-l-carboxylate 22 as a light yellow oil: 1H NMR (400 MHz, CD3CN) delta 4.18 (t, J = 4.8 Hz, 2H), 4.00 (m, 2H), 2.99 (s, 3H), 2.67 (m, 2H), 1.72 (m, 2H), 1.65 (m, 2H), 1.43 (m, IH), 1.41 (s, 9H), 1.30 (m, 2H), 1.01 (ddd, J = 3.3, 9.6, 18.6 Hz, 2H); MS calcd. for C9H20NO3S [M-Boc+H]+: 222.1, found: 221.9.

156185-63-6, 156185-63-6 tert-Butyl 4-(3-hydroxypropyl)piperidine-1-carboxylate 2800739, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; IRM LLC; WO2009/105717; (2009); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.373604-28-5,tert-Butyl 3-fluoro-4-hydroxypiperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

Sodium bis(trimethylsilyl)amide (0.24 ml_, 1 M in tetrahydrofuran) was added drop-wise to a solution of te/t-butyl 3-fluoro-4-hydroxypiperidine-1-carboxylate (48 mg, 0.22 mmol) in tetrahydrofuran (1 mL) at room temperature. The mixture was stirred for 5 minutes, before it was added drop-wise to a stirred solution of methyl 1-(6-chloro-5- methylpyrimidin-4-yl)indoline-5-carboxylate (60 mg, 0.2 mmol) in tetrahydrofuran (1 mL) at 60 degrees Celsius. The reaction mixture was stirred at 60 degrees Celsius for 2 hours. The reaction mixture was cooled to room temperature and diluted with water and ethyl acetate. The aqueous layer was extracted with ethyl acetate and the combined organic extracts were dried over magnesium sulfate, filtered and the filtrate was concentrated in vacuo. The crude 1-(6-(1-(te/t-butoxycarbonyl)-3-fluoropiperidin-4- yloxy)-5-methylpyrimidin-4-yl)indoline-5-carboxylic acid was used in the next step without purification.

373604-28-5, 373604-28-5 tert-Butyl 3-fluoro-4-hydroxypiperidine-1-carboxylate 42609254, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; PFIZER INC.; DAROUT, Etzer; DENINNO, Michael, Paul; FUTATSUGI, Kentaro; GUIMARAES, Cristiano, Ruch, Werneck; LEFKER, Bruce, Allen; MASCITTI, Vincent; MCCLURE, Kim, Francis; MUNCHHOF, Michael, John; ROBINSON, Ralph, Pelton, Jr.; WO2010/128414; (2010); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20845-34-5,1-Methyl-2-piperidinemethanol,as a common compound, the synthetic route is as follows.

The title compound was prepared by using Mitsunobu condition from 4-(2-hydroxy-phenyl)-piperazine-1-carboxylic acid tert-butyl ester and 1-Methyl-2-piperidinemethanol., 20845-34-5

As the paragraph descriping shows that 20845-34-5 is playing an increasingly important role.

Reference£º
Patent; Briner, Karin; Doecke, Christopher William; Mancuso, Vincent; Martinelli, Michael John; Richardson, Timothy Ivo; Rothhaar, Roger Ryan; Shi, Qing; Xie, Chaoyu; US2004/82590; (2004); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.157327-41-8,1-Boc-3-[(Dimethylamino)methylene]-4-oxopiperidine,as a common compound, the synthetic route is as follows.

Example 21ferf-Butyl 2-((3-cyanophenyl)amino)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)- carboxylate[00164]fe/f-Butyl 3-((dimethylamino)methylene)-4-oxopiperidine-1 -carboxylate (1 .1 g, 4.33 mmol) is dissolved in abs. EtOH (20 mL), and 1 -(3-cyanophenyl)guanidine (0.46 g, 2.90 mmol) is added. The mixture is heated at 100 C for 16 h, then cooled and evaporated to dryness. Purification of the residue by flash column chromatography provides the title compound (0.62 g, 60%) as a yellow solid.1H NMR (CDCI3), deltaEta, 1 .49 (s, 9H), 2.85 (t, 2H), 3.73 (t, 2H), 4.51 (s, 2H), 7.24 – 7.41 (m, 3H), 7.62 – 7.66 (m, 1 H), 8.20 (s, 1 H), 8.24 (s, 1 H)LC/MS (M+H)+ = 352

157327-41-8, 157327-41-8 1-Boc-3-[(Dimethylamino)methylene]-4-oxopiperidine 53395404, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; MERZ PHARMA GMBH & CO. KGAA; ABEL, Ulrich; KRUEGER, Bjoern; KUBAS, Holger; MEYER, Udo; ZEMRIBO, Ronalds; SMITS, Gints; WO2012/85167; (2012); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.147769-93-5,(S)-3-Methyl-1-(2-(piperidin-1-yl)phenyl)butan-1-amine,as a common compound, the synthetic route is as follows.

EXAMPLE 1 Preparation of Ethyl (S)-2-ethoxy-4-[N-[1-(2-piperidinophenyl)-3-methyl-1-butyl]aminocarbonylmethyl]benzoate In a round bottom flask fitted with a dean stark condenser, (S)-3-methyl-1-(2-piperidinophenyl)-1-butylamine (10 g, 0.0406 mol) was dissolved in toluene (100 ml), followed by the addition of 3-ethoxy-4-ethoxycarbonyl phenyl acetic acid (10.26 g, 0.0407 mol) and boric acid (0.26 g, 0.0042 mol). The reaction mixture was refluxed for 16-18 hours. The resulting mass was then cooled to 25-30 C. followed by filtration. The filtrate was washed with water and 1.0% sodium bicarbonate solution followed by complete distillation of toluene and the resulting residue was stirred with hexane (50 ml) for 1 hour. The precipitated solid was filtered and washed with hexane (10 ml). The wet product was dried at 50-55 C. under vacuum for 4-6 hours to produce Ethyl (S)-2-ethoxy-4-[N-(1-(2-piperidino-phenyl)-3-methyl-1-butyl)-aminocarbonyl methyl]-benzoate (Yield=73.3%; HPLC Purity: 99.50%).

147769-93-5, As the paragraph descriping shows that 147769-93-5 is playing an increasingly important role.

Reference£º
Patent; ACTAVIS GROUP PTC hf; US2008/200684; (2008); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

158407-04-6, tert-Butyl 4-(bromomethyl)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Method H; Synthesis of 2-Methyl-2-(piperidin-4-ylmethanesulfonyl)-N-(5-trifluoromethyl-pyridin-2-yl)-propionamide (Example 98, Table 17) Step 1: Synthesis of 4-[1-Methyl-1-(5-trifluoromethyl-pyridin-2-ylcarbamoyl)-ethylsulfanylmethyl]-piperidine-1-carboxylic acid tert-butyl ester To a solution of 200 mg (0.654 mmol) of thioacetic acid S-[1-methyl-1-(5-trifluoromethyl-pyridin-2-ylcarbamoyl)-ethyl]ester (synthesized according to Method F, step 1) in ethanol (2 mL) were added 363 mg (1.31 mmol) of 4-bromomethyl-piperidine-1-carboxylic acid tert-butyl ester and 141 mg (2.61 mmol) of sodium methoxide at room temperature. The reaction was heated to 130 C. for 0.5 h within a microwave (CEM Discover). The reaction mixture was concentrated under reduced pressure. The residue was dissolved in DCM (4 mL) and washed with saturated aqueous NaHCO3 solution (5 mL). The organic phase was dried over Na2SO4, filtered and the filtrate was concentrated under reduced pressure to yield 375 mg of 4-[1-methyl-1-(5-trifluoromethyl-pyridin-2-ylcarbamoyl)-ethylsulfanylmethyl]-piperidine-1-carboxylic acid tert-butyl ester., 158407-04-6

As the paragraph descriping shows that 158407-04-6 is playing an increasingly important role.

Reference£º
Patent; Berry, Angela; Cirillo, Pier Francesco; Hickey, Eugene Richard; Riether, Doris; Thomson, David; Zindell, Renee M.; Blumire, Nigel; Chowdhury, Chandana; Ermann, Monika; Jenkins, James Edward; Mushi, Innocent; Palmer, Christopher Francis; Taylor, Malcolm; US2008/81822; (2008); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

40064-34-4, Piperidine-4,4-diol hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,40064-34-4

Step 1 To a stirred, 0 C. solution of 4-piperidinone hydrochloride hydrate (50 g; 0.33 mol) in DMF (500 mL) was added di-t-butyldicarbonate (64 g; 0.29 mol) followed by a dropwise addition of DIEA (63 mL; 0.36 mol). After the addition of DIEA was complete, the reaction was allowed to gradually warm to ambient temperature over 4 h and stirring was continued for 20 h. The DMF was removed under reduced pressure and the residue was dissolved in EtOAc (1000 mL) and washed with 5% aqueous citric acid (2*500 mL), water (250 mL), and saturated aqueous NaHCO3 (500 mL). The EtOAc layer was dried (Na2 SO4), filtered, and the EtOAc was removed under reduced pressure. The residue was boiled in ether (ca. 250 mL) until the solid had dissolved. Cooling gave N-t-butyloxycarbonyl-4-piperidinone as white crystals (47 g; 80% yield).

40064-34-4 Piperidine-4,4-diol hydrochloride 33721, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Merck & Co., Inc.; US5665719; (1997); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem