Day: September 17, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7149-42-0,(1-Methylpiperidin-4-yl)methanamine,as a common compound, the synthetic route is as follows.

General procedure: Exam le: Synthesis of final product 1A mixture of (1-methyl-4-piperidinyl)methanamine (101 mg, 0.78 mmol) and Intermediate 1-42 (100 mg, 0.26 mmol) in DMA (5 mL) was heated at 100 C for 8 h. The solvents were removed in vacuo and the residue was purified by column chromatography (DCM/7N NH3 in MeOH 100:0 to 98:2). The product obtained was triturated from Et20 to afford Final Product 1 (32 mg) as a white solid., 7149-42-0

The synthetic route of 7149-42-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO); MCNEENEY, Stephen, Phillip; PASTOR FERNANDEZ, Joaquin; MARTINEZ GONZALES, Sonia; MARTIN HERNANDO, Jose Ignacio; RODRIGUEZ HERGUETA, Antonio; RICO FERREIRA, Maria del Rosario; BLANCO APARICIO, Carmen; WO2013/4984; (2013); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

138022-02-3, tert-Butyl 4-((methylamino)methyl)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(E)-3-(4-Chloro-2-((5-methyl-2 H-tetrazol-2-yl) methyl)phenyl)acrylic acid (Intermediate A)(200 mg, 0.718 mmol) and tert-butyl 4-((methylamino)methyl)piperidine-1-carboxylate (154mg, 0.718 mmol) were dissolved in DMF (3 ml). DIPEA (501 ul, 2.87 mmol) was added followed by 50percent T3P? solution in DMF (838 ul, 1.435 mmol) and the mixture was stirred at room temperature overnight. The resulting mixture was concentrated in vacuo. The residue was dissolved in EtOAc and washed with 10percent citric acid, saturated bicarbonate solution,brine, dried over MgSO4, filtered and concentrated in vacuo. Purification by chromatography on silica eluting with a gradient of EtOAc in iso-hexane afforded the title compound; LCMS: Rt 1.26 mins MS mlz 389.5 [M+H-Boc]+ Method 2minLowpHvol., 138022-02-3

138022-02-3 tert-Butyl 4-((methylamino)methyl)piperidine-1-carboxylate 21934652, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; NOVARTIS AG; BAETTIG, Urs; BEATTIE, David; LEGRAND, Darren Mark; LISTER, Andrew Stuart; MCKENNA, Jeffrey; PEARCE, David William; SANDHAM, David Andrew; STANLEY, Emily; STEWARD, Oliver Ross; THOMSON, Christopher; WO2015/8229; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

1312412-87-5, tert-Butyl 3-bromo-2,4-dioxopiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[0148] Method H-Step d: Tert-butyl 2-amino-4-oxo-6,7-dihydrothiazolo[5,4-c]pyridine- 5(4H)-carboxylate [0149] A mixture of tert-butyl 3-bromo-2,4-dioxopiperidine-l-carboxylate (292 mg, 1 mmol), thiourea (76 mg, 1 mmol) and NaHCC>3 (84 mg, 1 mmol) in ethanol (4 mL) was heated at 80C for 2 hours. The reaction mixture was then cooled to room temperature and the solids were filtered off. The filtrate was evaporated in vacuo to give a residue that was crystallized from EtOH. The white crystals thus obtained were filtered off and dried to yield 200 mg (74.3% for two steps). *H NMR (400 MHz, DMSO-i5) delta 8.08 (s, 2H), 3.89 (t, J Hz, 2H), 2.75 (t, / = 6.4 Hz, 2H), 1.44 (s, 9H)., 1312412-87-5

1312412-87-5 tert-Butyl 3-bromo-2,4-dioxopiperidine-1-carboxylate 69919790, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; ZHANG, Xiaohu; WO2014/113191; (2014); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

71233-25-5,71233-25-5, 1-tert-Butyl 4-ethyl 3-oxopiperidine-1,4-dicarboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of Na (4.24 g, 184 mmol, 4.37 mL, 2.50 eq) in EtOH (400 mL) was added 1 -tert- butyl 4-ethyl 3-oxopiperidine-l,4-dicarboxylate (20.0 g, 73.7 mmol, 1.00 eq) and acetic acid methanimidamide (11.5 g, 111 mmol, 1.50 eq) under N2. The mixture was stirred at 70 ¡ãC for 5 hours. The reaction mixture was adjusted to pH 7 with HCl (IN), extracted with DCM (3 x 200 mL), washed with brine (1 chi 400 mL), dried over Na2S04, filtered and concentrated under vacuum to give tert-butyl 4-hydroxy-6,8-dihydro-5H-pyrido [3,4-d]pyrimidine-7-carboxylate (16.0 g, 63.7 mmol, 86.4 percent yield) as a brown solid. ESI MS m/z 274.0 [M+H]+.

71233-25-5 1-tert-Butyl 4-ethyl 3-oxopiperidine-1,4-dicarboxylate 15852989, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; MIRATI THERAPEUTICS, INC.; ARRAY BIOPHARMA, INC.; FISCHER, John, P.; FELL, Jay, Bradford; BLAKE, James, F.; HINKLIN, Ronald, Jay; MEJIA, Macedonio, J.; HICKEN, Erik, James; CHICARELLI, Mark, Joseph; GAUDINO, John, J.; VIGERS, Guy, P.A.; BURGESS, Laurence, E.; MARX, Matthew, Arnold; CHRISTENSEN, James, Gail; LEE, Matthew, Randolf; SAVECHENKOV, Pavel; ZECCA, Henry, J.; (529 pag.)WO2017/201161; (2017); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

147539-41-1, tert-Butyl 4-(methylamino)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Intermediate 191a4-Methylamino-piperidine-l-carboxylic acid tert-butyl ester (500 mg, 1.87 mmol) was suspended in 10 ml of 1,2-dichloroethane. Tetrahydro-pyran-4-one (0.17 ml, 1.87 mmol) was added and the reaction mixture was stirred at room temperature for 30 min. Sodium triacetoxyborohydride (593 mg, 2.80 mol) was added and the reaction mixture was stirred for 18 h. The reaction mixture was diluted with dichloromethane and washed with an aqueous saturated sodium bicarbonate solution.The organic phase was dried over sodium sulfate and concentrated under vacuum. The crude product was purified by flash chromatography (Isolute silica gel cartridge 1Og; eluent: dichloromethane/methanol=94/6percent). 240 mg (0.80 mmol) of the desired compound were obtained., 147539-41-1

As the paragraph descriping shows that 147539-41-1 is playing an increasingly important role.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; EBEL, Heiner; FRATTINI, Sara; GIOVANNINI, Riccardo; HOENKE, Christoph; TRIESELMANN, Thomas; TIELMANN, Patrick; SCHEUERER, Stefan; HOBBIE, Silke (Marie Katrin); WO2010/70032; (2010); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

79421-45-7, 1-(4-Nitrophenyl)piperidin-4-ol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of the yellowish solid (0.90 g, 4.05 mmol) and palladium on carbon (Pd(C)) (10%, 120 mg) in methanol (MeOH) (20 mL) containing aqueous 6N HCl (0.20 mL) was hydrogenated under a balloon of H2 overnight. It was then filtered through celite. The filtrate was concentrated in vacuo to give 1-(4-aminophenyl)piperidin-4-ol as a solid (0.841 g)., 79421-45-7

As the paragraph descriping shows that 79421-45-7 is playing an increasingly important role.

Reference£º
Patent; PORTOLA PHARMACEUTICALS, INC.; US2009/54425; (2009); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

22065-85-6, 1-Benzylpiperidine-4-carbaldehyde is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

3-3) 1-Benzyl-4-[(5,6-diethoxy-1-indanon)-2-ylidene]methylpiperidine To a solution of 24.1 g of 5,6-diethoxy-1-indanone in 70 ml of THF was added 26.7 g of 1-benzyl-4-formylpiperidine in 100 ml of THF, followed by addition of a solution of 23.2 g of sodium methoxide (28% methanol solution) in 30 ml of THF under ice-cooling. After stirring for 2 hours as it was, the mixture was poured onto ice water, and the precipitated solid was collected by filtration and dried. The product was recrystallized from ethyl acetate-ethanol, to give 39.6 g (89%) of the title compound as white crystals., 22065-85-6

The synthetic route of 22065-85-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Eisai Co., Ltd.; EP1468684; (2004); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

187834-88-4, 1-Boc-isonipecoticacidhydrazide is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of Compound [CCCX1H] (600 mg, 2.47 mmol), Compound [CCCXTV] (291 mg, 2.47 mmol), and sodium methoxide (266 mg, 25 wt% solution in methanol) in 2-ethoxyethanol (6 mL) was heated at 125 C for 16 h. The reaction mixture was partitioned between EtOAc and saturate aqueous ammonium chloride solution. The aqueous layer was extracted with additional EtOAc. The combined organic layer was dried over Na2SO4, filtered, and concentrated. The crude material was purified by ISCO to obtain Compound [CCCXVJ as a colorless oil (73.3 mg, 9%). 1H NMR (400 MHz, CHLOROFORM-d) delta ppm 1.57 (s, 9 H) 1.77 – 1.95 (m, 2 H) 2.09 (d, J=2.44 Hz, 2 H) 2.62 (s, 3 H) 2.89 – 3.01 (m, 2 H) 3.06 (br. s., 1 H) 3.98 – 4.51 (m, 2 H) 7.22 (d, J=4.59 Hz, 2 H) 8.50 (d, >;4.93 Hz, 2 H) 9.07 (br. s., 1 H).

187834-88-4, 187834-88-4 1-Boc-isonipecoticacidhydrazide 22713165, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; MERCK SHARP &; DOHME CORP.; BANYU PHARMACEUTICAL CO., LTD.; FAN, Weiming; HAXELL, Thomas, F. N.; JENKS, Matthew, G.; KAWANISHI, Nobuhiko; LEE, Shuliang; LIU, Hao; MALASKA, Michael, J.; MOORE, Joseph, A., III; OGINO, Yoshio; ONOZAKI, Yu; PANDI, Bharathi; PEEL, Michael, R.; SAKAMOTO, Toshihiro; SIU, Tony; WO2010/104933; (2010); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

143900-44-1, (S)-tert-Butyl 3-hydroxypiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of (S)-1 -Boc-3-hydroxypiperidine (10.0 g, 49.7 mmol) and triethylamine (7.82 mL, 54.7 mmol in DCM (60 mL) under a nitrogen atmosphere, cooled at 0 ¡ãC, was added dropwise methanesulfonyl chloride (4.23 mL, 54.7 mmol). The mixture stirred for 1 h, diluted with water (60 mL) before being passed through a hydrophobic frit. The organic layer was concentrated under reduced pressure to afford fe/ -butyl (3S)-3-methylsulfonyloxypiperidine-1 -carboxylate (13.9 g, 49.7 mmol, 100percent yield) as a colourless solid. H-NMR (400 MHz, DMSO-c/6): delta (ppm) 4.76-4.71 (m, 1 H, CH), 3.69-3.66 (m 1 H), 3.65-3.60 (m, 1 H), 3.49-3.43 (m, 1 H), 3.37-3.31 (m, 1 H), 3.07 (s, 3H, CH3), 2.02-1 .96 (m, 1 H), 1 .94-1 .91 (m, 1 H), 1 .87- 1 .80 (m, 1 H), 1 .59-1 .53, 1 .48-1 .45 (m, 9H), 143900-44-1

The synthetic route of 143900-44-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; REDX PHARMA LIMITED; ARMER, Richard; BINGHAM, Matilda; MORRISON, Angus; CARSWELL, Emma; ELUSTONDO, Fred; WALKER, Rolf; GUISOT, Nicolas; LUCAS, Catherine; WO2014/188173; (2014); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

106-52-5, 1-Methylpiperidin-4-ol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of N-methyl piperidinol (0.22 g, 1.96 mmol) and sodium hydroxide (79 mg, 1.96 mmol) in benzene (10 mL) was heated to reflux for 2 hours with stirring under nitrogen atmosphere and then cooled to 25 C. followed by the addition of compound 133 (0.25 g, 0.65 mmol) at same temperature. The mixture was heated to reflux for 6 hours, concentrated under vacuum and diluted with water (10 mL). The precipitated solid was filtered and purified by column chromatography (5-10% MeOH-CHCl3) to afford the title compound E26 as a pale yellow solid (0.16 g, 53%). HPLC: Hichrom RPB (250*4.6 mm) 5 microns [solvent A=0.01 M KH2PO4 (pH 7.0); solvent B=CH3CN], Gradient elution program: T/% B=0/60, 10/60, 25/80, 40/80, 45/60, 50/60; 270 nm, Rt 35.21 min, 98.09% purity; MS (CI): m/z 461 (M+H, 50), 364 (100).

106-52-5, As the paragraph descriping shows that 106-52-5 is playing an increasingly important role.

Reference£º
Patent; Timmer, Richard T.; Alexander, Christopher W.; Pillarisetti, Sivaram; Saxena, Uday; Yeleswarapu, Koteswar Rao; Pal, Manojit; Reddy, Jangalgar Tirupathy; Krishna Reddy, Velagala Venkata Rama Murali; Sridevi, Bhatlapenumarthy Sesha; Kumar, Potlapally Rajender; Reddy, Gaddam Om; US2004/209881; (2004); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem