Day: September 7, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.959795-70-1,4-(4-(4-Methylpiperazin-1-yl)piperidin-1-yl)aniline,as a common compound, the synthetic route is as follows.

959795-70-1, 2-Methanesulfmyl-7-(2-methoxy-phenyl)-pyrrolo[2, 1 -f] [ 1 ,2,4]triazine (125.0 mg, 0.0004350 mol), N,N-Dsopropylethylamine (0.114 mL, 0.000652 mol) and 4-[4-(4- Methyl-piperazin-l-yl)-piperidin-l-yl]-phenylamine (0.239 g, 0.000870 mol) were dissolved in l-Methoxy-2-propanol (1.2 mL, 0.013 mol) and the reaction was irradiated at 300 watts , 1800C for 40 minutes or until HPLC showed consumption of starting material. The reaction mixture was then reduced en vacuo and the product was isolated and purified by Gilson prep HPLC to afford 164.97 mg of [7-(2-Methoxy-phenyl)-pyrrolo[2,l- f][ 1 ,2,4]triazin-2-yl]- {4-[4-(4-methyl-piperazin- 1 -yl)-piperidin- 1 -yl]-phenyl} -amine as a lyophilized powder. (M+H) = 498.9. 1U NMR (400 MHz, DMSO, d6) delta 9.42 (s, IH), 8.94 (s, IH), 7.80 (dd, IH, J = 1.60, 6.00 Hz), 7.69 (d, 2H, J = 8.93 Hz), 7.46 (m, IH), 7.20 (d, IH, J = 8.28 Hz), 7.13 (m, 3H), 6.94 (m, 2H), 3.70 (s, 3H), 3.67 (m, 7H), 3.01 (m, 6H), 2.83 (s, 3H), 2.07 (m, 2H), 1.79 (m, 2H).

As the paragraph descriping shows that 959795-70-1 is playing an increasingly important role.

Reference£º
Patent; CEPHALON, INC.; BRESLIN, Henry J.; CHATTERJEE, Sankar; DIEBOLD, James L.; DORSEY, Bruce D.; DUNN, Derek; GINGRICH, Diane E.; HOSTETLER, Greg A.; HUDKINS, Robert L.; HUNTER, Rachael; JOSEF, Kurt; LISKO, Joseph; MESAROS, Eugen F.; MILKIEWICZ, Karen L.; OTT, Gregory R.; SUNDAR, Babu G.; THEROFF, Jay P.; THIEU, Tho; TRIPATHY, Rabindranath; UNDERINER, Theodore L.; WEINBERG, Linda; WELLS, Gregory J.; ZIFICSAK, Craig A.; WO2010/71885; (2010); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

1892-22-4, 3-Aminopiperidin-2-one is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A suspension of 4 ‘- [(25) -2- {[(GammaalphaMu5-4- {[(betaGamma-BetaupsilonIotaomicron gammaomicron ^ omicronetagamma1) alphaetaiotaetaomicron] etaiotaepsilon11iotagamma1} omicrongammaomicron1omicron1iotaepsilon gamma1) – carbonyl] amino} -3- (l / i- indazol-6-ylamino) -3-oxopropyl] -2-methylbiphenyl-4-carboxylic acid (100 mg, 0.153 mmol) in ethyl acetate (2.5 ml) was treated with 3-aminopiperidine-2-one (19.2 mg, 0:17 mmol) and N , N-diisopropylethylamine (0.08 mL, 0:46 mmol).The suspension was treated with a 2,4,6-tripropyl-l, 3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide solution (50% in DMF, 0.27 mL, 0.46 mmol) and then 3 at reflux (oil bath temperature 80 C) stirred.The reaction mixture was added with DMF (1 ml) and the ethyl acetate was removed on a rotary evaporator.The residue was mixed with a little water and acetonitrile, filtered through a Millipore filter and purified by preparative HPLC (eluent: gradient of acetonitrile / water with 0.1% trifluoroacetic acid).This gave 49.1 mg (42% d. Th.) Of the title compound., 1892-22-4

1892-22-4 3-Aminopiperidin-2-one 5200225, apiperidines compound, is more and more widely used in various.

Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; ROEHN, ULRIKE; ELLERMANN, MANUEL; STRASSBURGER, JULIA; WENDT, ASTRID; ROEHRIG, SUSANNE; WEBSTER, ROBERT ALAN; SCHMIDT, MARTINA VICTORIA; TERSTEEGEN, ADRIAN; BEYER, KRISTIN; SCHAEFER, MARTINA; BUCHMUELLER, ANJA; GERDES, CHRISTOPH; SPERZEL, MICHAEL; SANDMANN, STEFFEN; HEITMEIER, STEFAN; HILLISCH, ALEXANDER; ACKERSTAFF, JENS; TERJUNG, CARSTEN; (489 pag.)TW2016/5810; (2016); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

141699-59-4, tert-Butyl 4-((methylsulfonyl)oxy)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

B. To a cold solution (0 ¡ãC) of 4-bromo-lH-pyrazole (14.9 g, 0.10 mol) in 80 mL of dichloromethane was added sodium hydride (8.13 g, 0.20 mol) portion wise. The mixture was stirred at 0 ¡ãC for 1 hour, followed by the addition of a solution of tert-butyl 4-((methylsulfonyl)oxy)piperidine-l-carboxylate (34.0 g, 0.12 mol) in 30 mL of N,N-dimethylformamide. The resulting mixture was heated at 110 ¡ãC overnight. Purification by column chromatography afforded tert-butyl 4-(4-bromo-lH- pyrazol-l-yl)piperidine-l-carboxylate as a yellow oil in 58percent yield (19.5 g). 1H NMR (400 MHz, CDC13) delta 7.48 (s, 1H), 7.44 (s 1H), 4.35-4.20 (m, 3H), 2.95-2.85 (m, 2H), 2.15-2.05 (m, 2H), 1.92-1.81 (m, 2H), 1.48 (s, 9H)., 141699-59-4

The synthetic route of 141699-59-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SIGNALCHEM LIFESCIENCES CORPORATION; ZHANG, Zaihui; WO2015/81257; (2015); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

940890-90-4,940890-90-4, (S)-tert-Butyl 3-((methylsulfonyl)oxy)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a 50-mL sealed tube was added tert-butyl (3S)-3- (memanesulfonyloxy)piperiPatent; ARDELYX, INC.; DRAGOLI, Dean; DOTSENKO, Irina; LEWIS, Jason; (439 pag.)WO2018/129552; (2018); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.873924-08-4,tert-Butyl 9-oxo-3-azaspiro[5.5]undecane-3-carboxylate,as a common compound, the synthetic route is as follows.

Tert-butyl 9-oxo-3-azaspiro[5.5]undecane-3-carboxylate (2.15 g, 8.05 mmol) was dissolved in EtOH (20 mL), and thereto was added a methylamine ethanol solution (33% [w / w], 3.7 g, 40.3 mmol), and the reaction solution was stirred at room temperature for 1.5 hours. Then NaBH3CN (1.5 g, 24.2 mmol) was added and after the addition was complete the reaction mixture was stirred at room temperature overnight. After the reaction was completed, the residue was concentrated under reduced pressure and the resulting residue was purified by silica gel column chromatography (DCM / MeOH (v / v) = 10/1) to give the title compound as a yellow oil (1.05 g, 46.2%)., 873924-08-4

As the paragraph descriping shows that 873924-08-4 is playing an increasingly important role.

Reference£º
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jiatuo Sciences Corporation; Xi Ning; Li Minxiong; Hu Haiyang; Wang Tingjin; (91 pag.)CN104672250; (2017); B;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1454-53-1,Ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride,as a common compound, the synthetic route is as follows.

Step A:l-Benzyl-3-ethoxycarbonyl-4-piperidone hydrochloride (12.89 g, 43.3 mmol) was suspended in a sodium methoxide solution in methanol (25 % wt/wt, 50 mL, 216. 2 mmol) and formamidine acetate (5.4 g, 51.9 mmol) was added to the mixture. The reaction mixture was refluxed until all of the starting material was consumed (2 h). The methanol was removed under reduced pressure, and the resulting white solid was dissolved in a 3/1 mixture of chloroform / isopropanol. The mixture was washed with water and brine, dried over Na2S04, filtered and evaporated to give the desired product as a white solid (9.4 g). MS (ESEI): 242.1 [M+l]+, 1454-53-1

The synthetic route of 1454-53-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; COBURN, Craig; WANG, Jiabing; SANTARELLI, Vince; HU, Shuangxi; CUI, Mingxiang; HU, Bin; DONG, Jingchao; LUO, Yunfu; SOLL, Richard, M; WO2011/103715; (2011); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

184637-48-7, tert-Butyl 3-aminopiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Tert-butyl piperidin-3-ylcarbamate (1.027 g, 5.117 mmol) with2-bromoethyl acetate (0.712 g, 4.264 mmol) and K2CO3 (0.589 g,4.264 mmol) in acetonitrile (42 mL) was heated at reflux for 24 h.When the reaction was finished the solvent was evaporated underreduced pressure, producing a residue that was then dissolved in20 mL of ethyl acetate and washed with saturated solution ofNaHCO3 (3 x 20 mL) and saturated solution of NaCl (30 mL). Theorganic extract was dried over anhydrous Na2SO4, filtered andconcentrated under vacuum. The crude product was purified byflash column chromatography in gradient of DCM/MeOH (9.6/0.4 to9.4/0.6, v/v) yielding product 53 as an oil (0.675 g, yield 55percent). TLCDCM/MeOH (9.5/0.5, v/v) Rf 0.24. MW 286.37. Formula:C14H26N2O4. MS m/z 287.28 (M+H+). 1H NMR (300 MHz, CDCl3)delta ppm 4.94-5.09 (m, 1H), 4.18-4.22 (m, 1H), 4.11-4.18 (m, 2H),3.80-3.85 (m, 1H), 2.43-2.61 (m, 4H), 2.26-2.42 (m, 2H), 2.05 (s,3H), 1.47-1.62 (m, 3H), 1.43 (s, 9H)., 184637-48-7

As the paragraph descriping shows that 184637-48-7 is playing an increasingly important role.

Reference£º
Article; Panek, Dawid; Wi?ckowska, Anna; Wichur, Tomasz; Bajda, Marek; Gody?, Justyna; Jo?czyk, Jakub; Mika, Kamil; Janockova, Jana; Soukup, Ondrej; Knez, Damijan; Korabecny, Jan; Gobec, Stanislav; Malawska, Barbara; European Journal of Medicinal Chemistry; vol. 125; (2017); p. 676 – 695;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

163271-08-7, tert-Butyl (4-methylpiperidin-4-yl)carbamate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Methanesulfonyl chloride (0.18 ml_) was added to a solution of 3-[2-(3-{[tert- butyl(dimethyl)silyl]oxy}-2,2-dimethylpropyl)-4-(1 -hydroxyethyl)-1 -oxo-1 ,2- dihydroisoquinolin-6-yl]-Lambda/-cyclopropyl-5-fluoro-4-methylbenzamide (Example 41a, 1.1 g) and triethylamine (0.66 ml_) in DCM (9 ml_) at 0 0C. The solution (total volume 11 mL) was stirred for 10 min and then 1 h at room temperature to afford a stock solution (11 mL). Aliquots of this were used directly without further purification to prepare examples 41 – 45.A solution of terf-butyl (4-methylpiperidin-4-yl)carbamate (74 mg) in DCM (1 mL) was added to a 1 mL aliquot of the above stock solution and the reaction stirred for 20 h. 4 M HCI in dioxane (1 mL) was added and the reaction allowed to stir for a further 20 h. The volatiles were removed in vacuo and the crude material was dissolved in methanol (2 mL) and loaded onto a 10 g SCX cartridge. The impurities were washed through with methanol (75 mL) and discarded. The product was eluted with 1 N methanolic ammonia (75 mL) and evaporated in vacuo. Purification by preparative HPLC (Gemini-NX C18 column using a 95-5 % gradient of aqueous 0.1 % ammonia in methanol as eluent) afforded the title product (10 mg) as a solid. MS: APCI(+ve) 563 (M+H)+ 1H NMR delta (DMSO-Cl6) 8.52 (d, 1H)1 8.36 (d, 1H), 8.17 (s, 1H), 7.68 – 7.64 (m, 2H), 7.53 (dd, 1 H), 7.34 (s, 1H), 4.89 (t, 1H), 4.10 (s, 1 H), 3.94 (dd, 2H), 3.84 (q, 1 H), 3.32 (s, 4H), 3.17 (s, 1 H), 3.11 (d, 2H), 2.85 (sextet, 1H), 2.60 – 2.32 (m, 4H), 2.23 (d, 3H), 1.33 (d, 3H), s 0.98 (s, 3H), 0.87 (s, 6H), 0.69 (td, 2H), 0.58 – 0.54 (m, 2H)

163271-08-7, As the paragraph descriping shows that 163271-08-7 is playing an increasingly important role.

Reference£º
Patent; ASTRAZENECA AB; BROUGH, Stephen, John; LUKER, Timothy, Jon; ROBERTS, Bryan, Glyn; ST-GALLAY, Stephen, Anthony; WO2010/39079; (2010); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1215071-17-2,tert-Butyl 3,3-difluoro-4-oxopiperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

tert-butyl 4-(2-ethoxy-2-oxoethylidene)-3,3-dimethylpiperidine-1-carboxylate At 0 C., to a solution of ethyl (diethoxyphosphoryl)formate (950 mg, 4.52 mmol) in THF (50 mL) was added sodium hydride (102 mg, 4.25 mmol) at 0 C. The resulting mixture was stirred for 15 min and then was added by tert-butyl 3,3-difluoro-4-oxopiperidine-1-carboxylate (798 mg, 3.39 mmol) at 0 C. The reaction mixture was stirred for 0.5 h at 0 C., warmed up to room temperature and stirred for 3 h at room temperature. When the reaction was done, it was quenched by the addition of water (20 mL). The resulting mixture was extracted with ethyl acetate (40 mL*3). The organic phases were combined, washed with brine and dried over Na2SO4. The solvent was removed under reduced pressure and the residue was purified by flash chromatography eluting with EtOAc in petroleum ether (0% to 50% gradient) to yield tert-butyl 4-(2-ethoxy-2-oxoethylidene)-3,3-dimethylpiperidine-1-carboxylate as colorless oil (560 mg, 35%). MS: m/z=205.9 [M-100+1]+., 1215071-17-2

1215071-17-2 tert-Butyl 3,3-difluoro-4-oxopiperidine-1-carboxylate 56776981, apiperidines compound, is more and more widely used in various.

Reference£º
Patent; Merck Patent GmbH; SHERER, Brian A.; BRUGGER, Nadia; LAN, Ruoxi; CHEN, Xiaoling; (60 pag.)US2019/23687; (2019); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

146093-46-1, 4-(Aminoethyl)-1-N-Boc-piperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

G.i. 7-((2-(l-(tert-butoxycarbonyl)piperidin-4-yl)ethyl)amino)-l-cyclopropyl-6-fluoro-4-oxo- 1, 4-dihydro-l,8-naphthyridine-3-carboxylic acid: Starting from 7-chloro- 1 -cyclopropyl-6-fluoro- 1 ,4-dihydro-4-oxo- 1 ,8-naphthyridine-3- carboxylic acid (311 mg; CAS 100361-18-0; commercial) and 4-(2-aminoethyl)-l- piperidinecarboxylic acid tert-butyl ester (194 mg; CAS 146093-46-1; commercial) and proceeding in analogy to preparation A, step A.ii, the title compound was obtained as a colorless solid (240 mg; 46% yield). MSI (ESI, m/z): 475.27 [M+H+]; tR = 0.95 min., 146093-46-1

146093-46-1 4-(Aminoethyl)-1-N-Boc-piperidine 1514258, apiperidines compound, is more and more widely used in various.

Reference£º
Patent; ACTELION PHARMACEUTICALS LTD; ENDERLIN-PAPUT, Stephanie; HUBSCHWERLEN, Christian; RUEEDI, Georg; ZUMBRUNN, Cornelia; WO2014/178008; (2014); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem