Day: August 18, 2020

91419-48-6, tert-Butyl 4-carbamoylpiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

under room temperature, nitrogen protection, (27.36g, 0 . 12mol, 1eq), laurance reagent (24.26g, 0 . 06mol, 0 . 5eq), mixed, added into the 1,4-dioxane 250 ml, the mixing tabs 50 C, 4h. Quality monitoring, after the reaction is complete. The reaction system can be obtained direct turns on lathe does target product 51. 86g crude product (containing laurance reagent decay product), purity 50%. The crude product of viscosity is very high bombycinous oily liquid.

The synthetic route of 91419-48-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Beijing Agricultural High-tech R & D Center Deere music; Beijing Century Dade Environmental Protection Technology Co., Ltd.; Yang, Fangli; (17 pag.)CN105541830; (2016); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

309956-78-3, (R)-tert-Butyl piperidin-3-ylcarbamate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound 5b (460 mg, 0.96 mmol) was dissolved in N, N-dimethylformamide (12 ml) by a known method, and (R) -3-tert-butoxycarbonylaminopiperidine (193 mg, 0.96 mmol) ,Potassium carbonate (200mg, 1.44mmol)was added, The reaction solution was cooled to room temperature, poured into cold water, filtered, washed with water and dried to give 5c (417 mg, gray solid), and the reaction mixture was cooled to room temperature. , Yield: 72.6%.

309956-78-3 (R)-tert-Butyl piperidin-3-ylcarbamate 1514172, apiperidines compound, is more and more widely used in various.

Reference£º
Patent; Chengdu YuanDong Biological Pharmaceutical Co., Ltd; WANG, YING; XIANG, YONGZHE; CENG, GUODONG; (21 pag.)CN103936738; (2016); B;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

79098-75-2, 3-Piperidin-4-yl-3,4-dihydro-1H-quinazolin-2-one is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 89 (+)-N-(1-(1-(3-Fluorobenzyl)-4-methyl-lH-imidazol-2-yl)-2-(7-methyl-lH- indazol-5-yl) ethyl)-4-(2-oxo-1, 2-dihydroquinazolin-3 (4H)-yl) piperidine-1- carboxamide tert-Butyl 1-(1-(3-fluorobenzyl)-4-methyl-11 J-imidazol-2-yl)-2-(7-methyl- 2- ( (2- (trimethylsilyl) ethoxy) methyl)-2H-indazol-5-yl) ethylcarbamate (20.0 mg, 0.034 mmol) was dissolved in a minimum amount of ethyl acetate, and treated with hydrochloric acid (4 N in dioxane, 1.0 mL). The mixture was stirred under nitrogen for 3 days. After removal of the solvents, the crude mixture was treated with diethyl ether to give a precipitate which was filtered. The resulting solid was dissolved in dimethylformamide (1.0 mL), cooled to 0C, and treated with carbonyl diimidazole (6.0 mg, 0.037 mmol, 1.1 equiv) and N’N- diisopropylethylamine (24. 3 L, 3 equiv). The reaction was stirred for 5 min at 0C, warmed to room temperature, stirred for 10 min, and treated with 3- (piperidin-4-yl) -3,4-dihydroquinazolin-2 (1H)-one (8.5 mg, 0.037 mmol, 1.1 equiv). The mixture was stirred at room temperature overnight. The solvent was evaporated and the residue purified by column chromatography to afford 16.1 mg (74%, 2steps).’H-NMR (CD30D, 500 MHz) 8 1.50-1. 68 (m, 4H), 2.27 (s, 3H), 2.46 (s, 3H), 2.77 (m, 2H), 3.20 (m, 2H), 4.01-4. 16 (m, 2H), 4.20 (s, 2H), 4.32- 4.43 (m, 1H), 5.13-5. 22 (m, 2H), 6.60-6. 67 (m, 2H), 6.70 (s, 1H), 6.76-6. 86 (m, 2H), 6.87-6. 94 (m, 1H), 6.96 (dd, J=8. 3,6. 7, 1H), 7.07-7. 14 (m, 2H), 7.16 (dd, J= 7.9, 7.6, 1H), 7.25 (s, 1H), 7.92 (s, 1H). Mass spec.: 621.4 (MH) +.

79098-75-2 3-Piperidin-4-yl-3,4-dihydro-1H-quinazolin-2-one 11042597, apiperidines compound, is more and more widely used in various.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2005/56550; (2005); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.479630-08-5,1-Boc-4-(2-Ethoxycarbonyl-acetyl)piperidine,as a common compound, the synthetic route is as follows.

Tert-butyl 4-(3-ethoxy-3-oxopropanoyl)piperidine-l -carboxylate (1.00 g, 3.34 mmol, 1.5 eq), 4- (trifluoromethyl)-lH-indazol-3-amine (448 mg, 2.27 mmol, 1 eq) and potassium phosphate (945 mg, 4.45 mmol, 2 eq) were suspended in l-methoxy-2-propanol (11.8 mL) in a 20 mL microwave vial. The vial was capped and the mixture was heated in a microwave to 180C for 15 min. After cooling to RT, the suspension was diluted with water (20 mL) and neutralized (pH 5) by the addition of IN HCl and extracted with ethyl acetate (2x 30 mL). The combined organic phases were washed with brine (10 mL), dried over sodium sulfate, filtered and evaporated in vacuo. The brown residue was purified by preparative HPLC (Method 1A). The combined product fractions were evaporated in vacuo to remove acetonitrile. The resulting suspension was filtered, the residue was washed with water (2 ml) and dried for 16 h at 50C in vacuo to yield the title compound (116 mg, 12% of theory) as colorless solid. LC-MS (Method IB): Rt = 1.19 min, MS (ESIPos): m/z = 437 [M+H]+

479630-08-5 1-Boc-4-(2-Ethoxycarbonyl-acetyl)piperidine 6618868, apiperidines compound, is more and more widely used in various.

Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; HASSFELD, Jorma; KINZEL, Tom; KOeBBERLING, Johannes; CANCHO-GRANDE, Yolanda; BEYER, Kristin; ROeHRIG, Susanne; KOeLLNBERGER, Maria; SPERZEL, Michael; BURKHARDT, Nils; SCHLEMMER, Karl-Heinz; STEGMANN, Christian; SCHUHMACHER, Joachim; WERNER, Matthias; ELLERMANN, Manuel; WO2015/67549; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.22065-85-6,1-Benzylpiperidine-4-carbaldehyde,as a common compound, the synthetic route is as follows.

To a cooled solution of 1-benzyl-4-piperidinecarboxaldehyde (407 mg, 2.0 mmol) and propargylamine (165 mg, 3.0 mmol) in MeOH (6 mL) at 0 C, a small amount of CF3CO2H (5 drops) was added. After being stirred for 1 h, NaBH3CN (189 mg, 2.9 mmol) was added to the solution portionwsise. The mixture was stirred at rt overnight and then quenched with aqueous saturated NaHCO3. The mixture was concentrated in vacuo and then extracted with AcOEt.

The synthetic route of 22065-85-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Universitat Autonoma de Barcelona; Consejo Superior de Investigaciones Cientificas (CSIC); National University Corporation Okayama University; Universidad de Alcala; Esteban, Gerard; Unzeta, Mercedes; Inokuchi, Tsutomu; Marco-Contelles, Jose Luis; Samadi, Abdelouahid; Iriepa, Isabel; Ojima, Masaki; Li, Wang; EP2727916; (2014); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.169457-73-2,tert-Butyl 4-(2-bromoethyl)piperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

133a) tert-butyl 4-(2-((2Z)-2-(methylimino)-1,3-thiazol-3(2H)-yl)ethyl)-1-piperidinecarboxylate To a solution of tert-butyl 4-(2-bromoethyl)-1-piperidinecarboxylate (D. Brundish et al., J. Med. Chem., 42, 4584 (1999); 5.0 g) and 2-methylaminothiazole (O. Kemal et al., J. Chem. Soc. Perkin I, 5, 1569 (1981); 3.9 g) in DMF (50 ml) was added potassium iodide (5.7 g), and mixed at 80C for 12 hours. The reaction mixture was concentrated under reduced pressure, and the residue was dissolved in chloroform and a saturated aqueous potassium hydrogen carbonate solution. The organic layer was collected by separation, dried over anhydrous sodium sulfate, and then concentrated under reduced pressure. The residue was purified with silica gel column to obtain the title compound as a brown oil (1.25 g, 22%). NMR (CDCl3) delta: 1.06-1.21 (2H, m), 1.45 (9H, s), 1.47 (1H, m), 1.58-1.69 (4H, m), 2.59-2.74 (2H, m), 2.97 (3H, s), 3.75 (2H, t, J=7.4), 4.00-4.16 (2H, br), 5.90 (1H, d, J=4.9), 6.51 (1H, d, J=4.9).

169457-73-2 tert-Butyl 4-(2-bromoethyl)piperidine-1-carboxylate 10541625, apiperidines compound, is more and more widely used in various.

Reference£º
Patent; Takeda Pharmaceutical Company Limited; EP1695961; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

309956-78-3, (R)-tert-Butyl piperidin-3-ylcarbamate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE II 3-Methyl-7-(2-butyn-1-yl)-8-[(R)-3-(tert.-butyloxycarbonylamino)-piperidin-1-yl]-xanthine 11.00 g of (R)-3-tert.-butyloxycarbonylamino-piperidine are added to 15.00 g of 3-methyl-7-(2-butyn-1-yl)-8-bromo-xanthine and 16.00 g of potassium carbonate in 100 ml of dimethylsulphoxide and the thick, light beige suspension is stirred for four hours with a mechanical stirrer at approx. 114 C. Then another 900 mg of (R)-3-tert.-butyloxycarbonylamino-piperidine, dissolved in 10 ml of dimethylsulphoxide, are added to the reaction mixture and this is stirred for a further two hours at 114 C. After cooling to ambient temperature the reaction mixture is diluted with copious amounts of water. The precipitate formed is thoroughly triturated until no more clumps are left, and suction filtered. The light solid is again suspended with water, suction filtered, washed with water and diethyl ether and dried in the circulating air dryer at 60 C. Yield: 19.73 g (94% of theory) Rf value: 0.64 (silica gel, ethyl acetate) Mass spectrum (ESI+): m/z=417 [M+H]+

As the paragraph descriping shows that 309956-78-3 is playing an increasingly important role.

Reference£º
Patent; Boehringer Ingelheim International GmbH; US2005/143377; (2005); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.29608-05-7,4-(Piperidin-1-ylmethyl)aniline,as a common compound, the synthetic route is as follows.

Compound 1 (2.0 g, 5.9 mmol) was refluxed for 2 hours in SOCl2. The reaction was cooled to RT and concentrated. The residue was taken up in DCM and concentrated a second time. The residue was then taken up in THF (25 mL) and added dropwise to a solution containing Compound Ik (1.1 g, 5.9 mmol), THF (25 mL) and DIPEA (2.5 mL, 14.4 mmol) at 0 0C. After 30 mins, the reaction was diluted with DCM and washed successively with 10% NH4Cl, water and brine. The organic layer was dried (Na2SO4), then filtered and treated with excess 2M HCl in ether to precipitate Compound 3 as an HCl salt (1.45 g). MS 537, 539 (MH+).

29608-05-7 4-(Piperidin-1-ylmethyl)aniline 846150, apiperidines compound, is more and more widely used in various.

Reference£º
Patent; JANSSEN PHARMACEUTICA, N.V.; WO2006/118749; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

845267-78-9, tert-Butyl 2,4-dioxopiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a mixture of 2,4-dioxo-piperidine-l-carboxylic acid tert-butyl ester (40 g, 187.58 mmol) in carbon tetrachloride (500 mL) was added N-bromosuccinimide (33.38 g, 187.58 mmol) portionwise keeping the reaction temperature in the range of 10C-15C. The mixture was further stirred at 10C-15C for 2 hours. The reaction mixture was allowed to warm to room temperature and the solvents evaporated in vacuo. The residue thus obtained was dissolved in AcOEt and washed with H20. The organic layer was separated, dried (Na2S04), filtered and the solvent evaporated in vacuo to yield 30 g (55%) of racemic intermediate 2 that was used in the next step without further purification.

845267-78-9 tert-Butyl 2,4-dioxopiperidine-1-carboxylate 23730999, apiperidines compound, is more and more widely used in various.

Reference£º
Patent; JANSSEN PHARMACEUTICA NV; MACDONALD, Gregor, James; TRESADERN, Gary, John; TRABANCO-SUAREZ, Andres, Avelino; PASTOR-FERNANDEZ, Joaquin; WO2011/73347; (2011); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.191805-29-5,tert-Butyl 1-oxo-8-azaspiro[4.5]decane-8-carboxylate,as a common compound, the synthetic route is as follows.

tert-Butyl 1-oxo-8-azaspiro[4.5]decane-8-carboxylate from Step G (4.5 g, 17.8 mmol) was dried by evaporating with toluene (10 mL) three times in vacuo, dissolved in tetrahydrofuran (100 mL), and cooled to -78 C. To this solution was added lithium diisopropylamide mono(tetrahydrofuran) (24 mL, 36 mmol, 1.5 M in cyclohexane). The reaction mixture was stirred for 30 min at -78 C. before adding propionaldehyde (2.6 mL, 36 mmol). After 5 min, the reaction mixture was diluted with diethyl ether, poured into saturated ammonium chloride, and extracted three times with diethyl ether. The organic layers were combined, washed with brine, dried over sodium sulfate, filtered, and concentrated to afford 6.7 g of a clear oil. The residue was purified by flash chromatography eluting with 20-30% ethyl acetate in hexanes to give the title compound (4.75 g). 1H NMR (400 MHz, CDCl3): delta 0.97 (t, 3 H), 1.33-1.37 (m, 2 H), 1.47 (s, 9 H), 1.54-1.68 (m, 5 H), 1.75-1.78 (m, 1 H), 2.07-2.13 (m, 2 H), 2.30-2.33 (m, 1 H), 2.95-3.15 (m, 2 H), 3.62-3.63 (m, 1 H), 3.84-3.94 (m, 2 H).

191805-29-5 tert-Butyl 1-oxo-8-azaspiro[4.5]decane-8-carboxylate 10848487, apiperidines compound, is more and more widely used in various.

Reference£º
Patent; Finke, Paul E.; Loebach, Jennifer L.; Parker, Kerry A.; Plummer, Christopher W.; Mills, Sander G.; US2005/70609; (2005); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem