Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane, Which mentioned a new discovery about 177-11-7
Unprotected secondary amines are directly alkylated by C-H functionalization adjacent to nitrogen, thereby opening new routes toward the synthesis of alpha- and beta-alkylated N-heterocycles. alpha-Alkylated piperidine, piperazine, and azepane products are prepared from heterocycles and alkenes in an atom-economic reaction with excellent regio- and diastereoselectivity. beta-Alkylated N-heterocycles are synthesized via a scalable one-pot alkylation/cyclization procedure generating 3-methylated azetidines, pyrrolidines, and piperidines.
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Reference：
Piperidine – Wikipedia,
Piperidine | C5H7176N – PubChem