Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， HPLC of Formula: C12H18N2, Which mentioned a new discovery about 50541-93-0
Retinoic acid receptor-related orphan receptor gamma (RORgamma), a member of the nuclear hormone receptor superfamily, is a promising therapeutic target for treating Th17-mediated autoimmune diseases. We performed structure-based virtual screening targeting the RORgamma ligand-binding domain. Among the tested compounds, s4 demonstrated RORgamma antagonistic activities with micromolar IC50 values in both an AlphaScreen assay (20.27 muM) and a cell-based reporter gene assay (11.84 muM). Optimization of the s4 compound led to the identification of compounds 7j, 8c, 8k, and 8p, all of which displayed significantly enhanced RORgamma inhibition with IC 50 values of 40-140 nM. These results represent a promising starting point for developing potent small molecule RORgamma inhibitors.
Because enzymes can increase reaction rates by enormous factors and tend to be very specific, HPLC of Formula: C12H18N2, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 50541-93-0
Reference：
Piperidine – Wikipedia,
Piperidine | C5H12435N – PubChem