A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Recommanded Product: 4727-72-4, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 4727-72-4, Name is 1-Benzylpiperidin-4-ol, molecular formula is C12H17NO. In a Article, authors is Catto, Marco，once mentioned of 4727-72-4
Acetylcholinesterase inhibitors (AChEIs) are currently the drugs of choice, although only symptomatic and palliative, for the treatment of Alzheimer’s disease (AD). Donepezil is one of most used AChEIs in AD therapy, acting as a dual binding site, reversible inhibitor of AChE with high selectivity over butyrylcholinesterase (BChE). Through a combined target- and ligand-based approach, a series of coumarin alkylamines matching the structural determinants of donepezil were designed and prepared. 6,7-Dimethoxycoumarin derivatives carrying a protonatable benzylamino group, linked to position 3 by suitable linkers, exhibited fairly good AChE inhibitory activity and a high selectivity over BChE. The inhibitory potency was strongly influenced by the length and shape of the spacer and by the methoxy substituents on the coumarin scaffold. The inhibition mechanism, assessed for the most active compound 13 (IC 50 7.6 nM) resulted in a mixed-type, thus confirming its binding at both the catalytic and peripheral binding sites of AChE.
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 4727-72-4, help many people in the next few years.Recommanded Product: 4727-72-4
Reference：
Piperidine – Wikipedia,
Piperidine | C5H12734N – PubChem