Related Products of 84163-77-9, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 84163-77-9, Name is 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole, molecular formula is C12H13FN2O. In a Article，once mentioned of 84163-77-9
To improve Alzheimer’s disease (AD) therapeutics, we have designed and synthesized new benzoisoxazole derivatives that are potent inhibitors of cholinesterase (acetylcholinesterase [AChE] and butyrylcholinesterase [BuChE]). Since inhibition of cholinesterase (ChE) is still considered to be one of the most effective ways of treating AD patients, many new classes of ChE inhibitors have been synthesized. To identify a new type of cholinergic drug, the benzoisoxazole moiety which is the pharmacophore moiety of Risperidone was coupled with natural antioxidants. Some benzoisoxazole derivatives (26-28 and 30) were found to effectively inhibit BuChE (IC50 < 20 muM), and some (20 and 26-28) to moderately inhibit AChE (IC50 < 100 muM). Furthermore, compound 28 showed better inhibitory activity against BuChE (IC50 = 0.72 ± 0.11 muM) than galantamine (IC50 = 8.4 ±0.1 muM). The new benzoisoxazole derivatives showing BuChE inhibitory activity represent a new class of ChE inhibitor and can be used to create novel compound derivative drugs for treating AD patients. Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Related Products of 84163-77-9, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 84163-77-9, in my other articles.
Reference：
Piperidine – Wikipedia,
Piperidine | C5H17748N – PubChem