Application of 84163-77-9, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.84163-77-9, Name is 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole, molecular formula is C12H13FN2O. In a Article，once mentioned of 84163-77-9
A series of novel conformationally restricted butyrophenones (2- (aminoethyl)- and 3-(aminomethyl)thieno- or benzocycloalkanones bearing (6- fluorobenzisoxazolyl)piperidine, (p-fluorobenzoyl)piperidine, (o- methoxyphenyl)piperazine, or linear butyrophenone fragments) were prepared and evaluated as atypical antipsychotic agents by in vitro assays of affinity for dopamine receptors (D1, D2) and serotonin receptors (5-HT2(A), 5- HT2(C)) and by in vivo assays of antipsychotic potential and the risk of inducing extrapyramidal side effects. Potency and selectivity depended mainly on the amine fragment connected to the cycloalkanone structure. As a group, compounds with a benzisoxazolyl fragment had the highest 5-HT2(A) activities, followed by the benzoylpiperidine derivatives; in general, alpha- substituted cycloalkanone derivatives were more active than the corresponding beta-substituted congeners. CoMFA (comparative molecular field analysis) and docking studies showed electrostatic, steric, and lipophilic determinants of 5-HT2(A) and D2 affinities and 5-HT2(A)/D2 selectivity. The in vitro and in vivo pharmacological profiles of N-[(4-oxo-4H-5,6- dihydrocyclopenta[b]thiophene-5-yl)ethyl]-4-(6-fluorobenzisoxazol-3- yl)piperidine (23b, QF 0510B), N-[(4-oxo-4,5,6,7- tetrahydrobenzo[b]thiophene-5-yl)ethyl]-4-(6-fluorobenzisoxazol-3- yl)piperidine (24b, QF 0610B), and N-[(7-oxo-4,5,6,7- tetrahydrobenzo[b]thiophene-6-yl)ethyl]4-(6-fluorobenzisoxazol-3- yl)piperidine (29b, QF 0902B) suggest that they may be effective antipsychotic drugs with low propensity to induce extrapyramidal side effects.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 84163-77-9
Reference：
Piperidine – Wikipedia,
Piperidine | C5H17840N – PubChem